Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
By M. Miyara, Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, Cécile Taflin, T. Heike, D. Valeyre and 8 more. Immunity, 2009
2,304 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/16bf23ef7711889212ec3011713f6c5329c828ed
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In Immunology
- Shimon Sakaguchi
- K. Wing
- T. Malek
- Atsushi Tanaka
- M. Miyara
- Naganari Ohkura
- J. Wing
- Tomoyuki Yamaguchi
Citations in the corpus
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “Although very high expression of IL-2Ra is readily achieved upon activation of conventional T cells in vitro, when T cells from mouse or man are directly evaluated ex vivo, the IL-2Ralo phenotype predominately associates with effector T cells (Kalia et al., 2010; Miyara et al., 2009).”
- Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases (2010, neutral): “Miyara et al.(21) defined these populations as a naive T Reg cell population that is CD25CD45RAFOXP3, an effector T Reg cell population that is CD25CD45RAFOXP3 and a non‐regulatory FOXP3 population that is CD25CD45RAFOXP3.”
- Regulatory T cells: how do they suppress immune responses? (2009, background): “vitro and are the only constitutive expressers of CTLA-4 ( 41 ).”
- Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, background): “In humans, terminally differentiated Foxp3 hi CD25 hi CD4 + T cells, which are highly suppressive in vitro , constitutively express CTLA-4 (ref”
- Regulatory T Cells and Human Disease. (2020, background): “III non-Tregs in patients with active SLE, indicating the expansion of activated Tconvs in the flare of the disease (40, 102).”
- FOXP3+ regulatory T cells in the human immune system (2010, background): “, T Reg cell-related immunobiology and molecular biology have now become a field of intense investigation, with FOXP3 + T Reg cells as a primary target in the search for new clinical application”
- Development and maintenance of regulatory T cells. (2013, background): “In contrast, T cells possessing Foxp3 expression but not the Treg-cell-type DNA hypomethylation pattern fail to exhibit sufficient Treg cell suppressive activity and instead secrete effector cytokines upon loss of Foxp3 expression (Miyao et al., 2012; Miyara et al., 2009; Ohkura et al., 2012).”