Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

By S. Allan, S. Q. Crome, N. Crellin, L. Passerini, T. Steiner, R. Bacchetta, M. Roncarolo, M. Levings. International Immunology, 2007

940 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/62ca30feb42c90b520ca13e31e167a9f6af9f627

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Citations in the corpus

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. (2012, background): “However, Foxp3 expression may not always specify Treg cells; in humans, activated T cells transiently upregulate FOXP3 without acquiring a Treg cell phenotype and function (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007; Ziegler, 2006), although such ‘‘promiscuous’’ Fox”
FOXP3+ regulatory T cells in the human immune system (2010, background): “Only ∼1–2% of cells with the highest CD25 expression have been shown to be functionally suppressive and can be considered T Reg cell”
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, neutral): “Although human CD4Foxp3(2) T cells can be induced to express Foxp3 by stimulation in vitro in the presence of TGF-b, they lack regulatory function (26, 27).”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “For example, it has been reported that mere TCR stimulation can induce FoxP3 expression in apparently naive human FoxP3 CD4 T cells without conferring suppressive activity (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007).”
1,25-dihydroxyvitamin D3 and interleukin-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 (2009, background): “Because the expression of FoxP3 in induced Tregs is thought to be transient (39, 40), we analyzed the kinetics of the response to determine whether 1,25(OH)2D3 treatment was able to sustain the expression of CTLA-4 and FoxP3.”
Development and maintenance of regulatory T cells. (2013, background): “For example, activated human Tconv cells transiently express FOXP3 at a low level without acquiring Treg cell suppressive activity (Allan et al., 2007).”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “…are not met by Foxp3: Whether after induction by TGF-b or after retroviral transduction, Foxp3 is not sufficient to elicit the full Treg cell signature (similarly, activated human Tconv cells express some Foxp3, yet show no suppressive characteristics [Walker et al., 2003; Allan et al., 2007]).”
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (2012, background): “Moreover, T cell receptor (TCR) stimulation can induce transient Foxp3 expression in naive T cells, but not suppressive activity, in humans (Allan et al., 2007; Miyara et al., 2009).”