The B7–CD28 superfamily

By Arlene H. Sharpe, G. Freeman. Nature reviews. Immunology, 2002

1,861 citations recorded by the source corpus.

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Citations in the corpus

Germinal-center organization and cellular dynamics. (2007, background): “The T cell costimulatory molecules CD28 and ICOS are also important, and the cytokines IL-4 and IL-21 contribute to the response (Cunningham et al., 2004; Ozaki et al., 2002; Reiter and Pfeffer, 2002; Sharpe and Freeman, 2002; Vajdy et al., 1995).”
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 (2003, background): “Both CTLA-4 and PD-1 interact with members of the B7 famil”
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 (2005, background): “CD28 is the main costimulatory molecule on T cells, and its ligands B7-1 (CD80) and B7-2 (CD86) are expressed mainly on B cells, dendritic cells and thymic medullary epithelial cells, although other cells may have low expression of B7 (ref”
The inflammatory response to cell death. (2008, background): “To become fully activated the T cell must also receive other costimulatory signals from the dendritic cell and these second signals are only provided if the dendritic cells have previously been stimulated in certain ways (104).”
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. (2004, neutral): “ICOS) or were shown to depend on IL4 for Th2 promotion (OX40, IL6)(Lane, 2000; Rincon et al., 1997; Sharpe and Freeman, 2002 ).”
Restoring function in exhausted CD8 T cells during chronic viral infection (2006, positive): “These phosphatases act on proximal signalling kinases of the TCR pathway, reducing the TCR signal and leading to diminished T-cell activation and cytokine production 12,13 .”
Inhibitory B7-family molecules in the tumour microenvironment (2008, neutral): “2), B7-DC (also known as PD-L2 or CD273), B7-H1 (also known as PD-L1 or CD274), B7-H2 (also known as ICOSL), B7-H3 (also known as CD276) and B7-H4 (also known as B7S1 or B7x”
CTLA-4: new insights into its biological function and use in tumor immunotherapy (2002, background): “Research over the past decade has established that engagement of CD28 on the T cell by B7-1 and B7-2 on the antigen-presenting cell (APC) provides signal 2, at least for naive T cell”
PD-1 signaling in primary T cells (2009, background): “In contrast to cytotoxic T-lymphocyte antigen-4 (CTLA-4) deficiency, which leads to a massive lymphoproliferative disorder within weeks of birth (7), PD-1 deficiency leads to species-specific autoimmunity that occurs much later in life (2).”
Cellular and genetic mechanisms of self tolerance and autoimmunity (2005, background): “Expression of another inhibitory receptor, cytotoxic T-lymphocyte antigen 4 (CTLA4), is induced at a high threshold of TCR self reactivity and inhibits T-cell activation by competing with CD28 for ligation with B7 molecules and by transmitting inhibitory signal”
Cytokines in cancer pathogenesis and cancer therapy (2004, background): “Tumour cells typically lack the expression of important co-stimulatory molecules, such as B7 family members, that are necessary to directly prime potent T-lymphocyte response”
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation (2011, background): “PD-L1 is one member of the B7 superfamily and more broadly expressed than the other B7 superfamily members [11, 12].”
PI3K in lymphocyte development, differentiation and activation (2003, background): “cgi?/&Q=cd80[sym]%20or%20cd86[sym]&ORG=Hs">B7 molecules (including CD80 and CD86), which are ligands for CD28, and the capacity of an APC to activate a T cell depends, to a large extent, on its expression of B7 (or related co-stimulatory) ligand”