Germinal-center organization and cellular dynamics.

By Christopher D. C. Allen, T. Okada, J. Cyster. Immunity, 2007

1,001 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0916c0f2e2f11753d9e269e1fcd4a508382ab1de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Physiology

Citations in the corpus

Follicular Helper T Cells. (2016, background): “This occurs through the antigen-specific Tfh-mediated selection of GC B cells, which enables them to undergo further rounds of division and SHM (25).”
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism (2010, background): “After a period of B cell proliferation, several processes are initiated within the GC that affect affinity maturation whereby the mean binding affinity of antigen-specific antibody increases as a function of time (MacLennan, 1994; Allen et al., 2007).”
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “T cells also provide help for B cell responses, and germinal centers (GCs) in lymphoid tissues serve as special sites where T cells select mutated high-affinity B cells and promote their differentiation to memory B cells and long-lived plasma cells during T celldependent antibody responses (Allen et”
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “CD4+ T cells are fundamental for the generation of germinal centers (GCs), a discrete structure in secondary lymphoid organs where selection of high-affinity B cells and development of B cell memory occur (Allen et al., 2007; MacLennan, 1994).”
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “It has been speculated that reduced competition for Tfh cells may lower the stringency of the selection process (Allen et al., 2007).”
Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, neutral): “…are necessary for GCmaintenance (Han et al., 1995a; Huntington et al., 2006), and that each of these signals is capable of extending B cell survival in vitro (Liu et al., 1989), evidence for one or the other as agents of selection in the GC is circumstantial (Allen et al., 2007a; Tarlinton, 2008).”
Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, positive): “Tfh cells first interact with cognate B cells at the T cell-B cell border and subsequently induce germinal center B 932 Immunity 34, 932–946, June 24, 2011 ª2011 Elsevier Inc. cell differentiation and germinal center formation within the follicle (Allen et al., 2007).”
GERMINAL CENTER B CELL DYNAMICS (2016, neutral): “Surprisingly, however, disruption of LZ-DZ polarity by deletion of CXCR4 has little if any effect on the efficiency of affinity maturation toward a hapten antigen (Nie et al., 2004) and leads only to a moderate decrease in the number of mutations accrued by B cells in influenza-induced and Peyer’s p”
Cytokine-secreting follicular T cells shape the antibody repertoire (2009, methodology): “To detect NP-specific antibodies in serum of immunized mice, 96-well plates were coated with NP(23)-BSA or NP(3)-BSA (Biosearch) and incubated with serial 5-fold dilutions of serum.”
From Vaccines to Memory and Back (2010, positive): “formation of germinal center reaction where TFH cells and antigen trapped on follicular dendritic cell (FDC) networks drive proliferation, isotype switch and affinity maturation of antigen-specific B cells leading to the generation of memory B cells and long-lived plasma cells that produce high affi”