Cytokines in cancer pathogenesis and cancer therapy

By G. Dranoff. Nature Reviews. Cancer, 2004

1,581 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b4707c2ef269b7bd0ee5dcda69791e11709725e9

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Citations in the corpus

Tumour-educated macrophages promote tumour progression and metastasis (2004, background): “cgi?l=3458">IFN-γ ), are likely to be important, as these direct macrophages towards more cytotoxic and antigen-presenting phenotype”
Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “The innate immune system is made up of cells from myeloid lineages, including monocytes, macrophages, dendritic cells, mast cells, natural killer cells, and the granulocytes: basophils, eosinophils, and neutrophils (26).”
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, neutral): “The specific cytokine profile is critical for eradicating pathogens and tumors (Dranoff, 2004; Iwasaki and Medzhitov, 2015).”
Interactions Between the Immune System and Cancer: A Brief Review of Non-spatial Mathematical Models (2011, background): “are the focus of many cancer immunotherapies, though the mechanisms through which they interact with cancer cells are not completely understood (Dranoff 2004; Kim-Schulze et al. 2007; Parmiani et al. 2000).”
Inflammation, a Key Event in Cancer Development (2006, background): “Cytokines, including IL, TNF-a, growth factors, and differentiation factors (colony-stimulating factors), are secreted or membrane-bound molecules that play a regulatory role in the growth, differentiation, and activation of immune cells (100).”
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients (2008, background): “T frequently provoke innate and adaptive immune recognition, but the development of clinically evident disease denotes a failure of host defense (1).”
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy (2005, positive): “dtd" [ ]> Immune cells create a complex cytokine environment that promotes cancer cell survival, angiogenesis, invasion and metastasi”
Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. (2012, background): “Tumour antigens are normal cellular proteins that are abnormally expressed as a result of genetic mutations, quantitative differences in expression, or differences in posttranslational modifications [5].”
NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “In this respect, vaccines against cancer are particularly attractiv”
Therapeutic targeting of the tumor microenvironment. (2005, neutral): “While there is a therapeutic benefit from these treat ments in some patients with melanoma, renal cell carcinoma, and prostate cancer, there are significant side effects associat ed with prolonged use (see Dranoff, 2004 for review).”
New signals from the invasive front (2006, background): “On the other hand, there have been many reports that the balance of secreted factors is tilted towards a cytokine/chemokine milieu that promotes tumour progression — for example, by angiogenic factors, inflammatory cytokines and MMP”