Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

By D. Amsen, J. Blander, G. Lee, Kenji Tanigaki, Tasuku Honjo, R. Flavell. Cell, 2004

974 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/af5fc1b5513d9b85807b51bc1c25f32fd376f8b4

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Citations in the corpus

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, neutral): “…and Jagged/Serrate ligands have different biological roles in many organs and tissues, for example in the developing nervous and immune systems (Amsen et al., 2004; Brooker et al., 2006), which has been attributed to spatiotemporal differences in ligand expression or the cellular context of…”
Farm living: effects on childhood asthma and allergy (2010, background): “; that is, the shifting of allergen-specific responses from the T H 2 to the T H 1 phenotype owing to microorganism-dependent induction of a Delta–Notch-mediated T H 1 cell-polarizing programme in dendritic cell”
Epigenetic control of T-helper-cell differentiation (2009, background): “For example, STAT6 binds to the Il4 and Il13 promoters and to HSV A , as well as to RHS6 and RHS7; GATA3 binds to the Il5 and Il13 promoters, to the first intron of Il4 , HSV A and RHS7, and to the Il13 HS1–CGRE region; and recombination-signal-binding protein for immunoglobulin-κ J regi”
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function (2005, background): “and fits the suggestion that T H 2-promoting PAMPs are not simply maturation stimuli but instead act on APCs to drive expression of a T H 2-inducing signal 3 such as the notch ligand jagged”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “Deletion of HSVa and HSV, which also contains a Notch ⁄CSL binding site (160), results in reduced IL-4 production.”
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “Furthermore, two Notch ligands, Delta-4 and Jagged-1, can be expressed by DCs and are capable of selectively inducing T H 1 or T H 2 differentiation, respectivel”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “2006), and the differentiation of CD4 T cells along either TH1 or TH2 pathways (Amsen et al. 2004; Tanigaki et al. 2004; Minter et al. 2005; Tu et al. 2005).”
Differentiation of Effector CD4 T Cell Populations (2010, neutral): “(233) reported that Jag1/Notch interaction directs Th2 differentiation, whereas Dll1/ Notch interaction leads to Th1 polarization.”
Dendritic cells: translating innate to adaptive immunity. (2006, neutral): “While much of the literature on maturation deals with the identification of stimuli that allow DCs to elicit strong Th1 type immunity, it is also necessary to understand how DCs induce a more classical “noninflammatory” Th2 pathway of T cell differentiation, where TNF is not produced.”
Expanding the effector CD4 T-cell repertoire: the Th17 lineage. (2006, background): “Also, it has recently been reported that APC expression of different Notch ligands can direct effector differentiation: Delta promotes Th1 differentiation, whereas Jagged promotes Th2 differentiation [ 50 ].”
Dendritic cells in a mature age (2006, background): “, perhaps by selectively expressing members of the Jagged family of Notch ligand”