PI3K in lymphocyte development, differentiation and activation

By K. Okkenhaug, B. Vanhaesebroeck. Nature reviews. Immunology, 2003

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Mechanism of B-Cell Receptor-Induced Phosphorylation and Activation of Phospholipase C-γ2 (2004, background): “production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by activating phosphatidylinositol (PI) 3-kinase (11, 32, 38).”
Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia (2014, neutral): “Decreased appetite 13 (12) 0 9 (8) 1 (1)”
The PI3K pathway in human disease (2017, positive): “Several comprehensive Reviews have receptors to regulate a variety of lymphocyte responses and how genetic deﬁciency or hyperactivity of PI3K isoforms can both lead to im-munodeﬁciency (Hawkins and Stephens, 2015; Lucas et al., 2016; Okkenhaug and Vanhaesebroeck, 2003).”
Intracellular signalling controlling integrin activation in lymphocytes (2005, background): “, studies using gene targeting of the catalytic subunits PI3K-γ or PI3K-δ did not show any defects indicative of reduced integrin functio”
Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 (2004, background): “1), we explored the possibility that p110 , a major PI3K isoform in lymphocytes (5, 6), was involved in B cell chemotaxis.”