The inflammatory response to cell death.

By K. Rock, H. Kono. Annual Review of Pathology, 2008

961 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/da5f9a479ed68e122ec0ef04796ceaa69b5718ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Tschopp
2. Fabio Martinon
3. E. Latz
4. S. Ghosh
5. Annick Mayor
6. R. Medzhitov
7. Shizuo Akira
8. A. West

In Molecular Biology

1. J. Tschopp
2. Fabio Martinon
3. E. Latz
4. Annick Mayor
5. H. Kono
6. K. Rock
7. J. Ting
8. R. Medzhitov

Citations in the corpus

• Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “Macrophages clear the dead cells in both cases; however, they typically repress inflammation when phagocytosing apoptotic cells and promote inflammation during necrotic cell removal.(20,21) Because ingesting dying hepatocytes, and dead cells in general, increases TGF-b1 secretion, in this case the p”
• Mitochondria in innate immune responses (2011, background): “Mitochondria and cellular damage responses In addition to recognizing a diverse array of microbial PAMPs, it is now well appreciated that PRRs of the innate immune system sense cellular damage and stress in the absence of microbial infectio”
• The sterile inflammatory response (2010, background): “For a more complete discussion of proinflammatory DAMPs interested readers are referred to recent reviews (47) (53).”
• Para-inflammation in the aging retina. (2009, background): “By contrast, during apoptotic cell death, the integrity of cell membrane is not disrupted initially and the DAMP molecules are contained within the apoptotic cells (Bianchi and Manfredi, 2007; Kono and Rock, 2008; Rock and Kono, 2008).”
• Origin and physiological roles of inflammation (2008, background): “During necrotic cell death, for example, the integrity of the plasma membrane is disrupted, resulting in the release of certain cellular constituents, including ATP, K p ions, uric acid, HMGB1 (high-mobility group box 1 protein) and several members of the S100 calcium-binding protein family (S100A8”
• The inflammasomes: guardians of the body. (2009, background): “This led to multiple studies identifying molecules and signals that are released by damaged or stressed tissues and that trigger or modulate the immune response (88, 89).”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “Cell death can be sensed by the innate immune system via the elaboration of DAMPs that are sensed by various pathways (36); however, the precise molecular moieties that are sensed are not clearly defined.”