Cellular and genetic mechanisms of self tolerance and autoimmunity

By C. Goodnow, J. Sprent, B. Groth, Carola G. Vinuesa. Nature, 2005

723 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/7952d31711b830ec1d543b1a7184de86915c4ce6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Nimmerjahn
2. J. Ravetch
3. F. Mackay
4. C. Mackay
5. B. Moser
6. Carola G. Vinuesa
7. Eric Wu
8. Hsin-jung Wu

Citations in the corpus

• Fcγ receptors as regulators of immune responses (2008, background): “Groundbreaking work over the last few years has established that several central and peripheral checkpoints exist throughout B-cell development to prevent the generation of autoreactive antibodie”
• Cracking the BAFF code (2009, background): “jpg" NDATA ITEM> ]> Immune cells produced in the bone marrow undergo a process of quality control, known as immune tolerance, that occurs throughout the life of B and T cells and that carefully selects useful protective immune cells while eliminating or neutralizing potentially harmfu”
• The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “Antagonism of B cell-activating factor of the tumor necrosis factor family (BAFF; also known as BLyS—B lymphocyte stimulator), an important survival factor for peripheral B cells, may be an alternative or an adjunct to Rituximab therapy to enhance autoimmune B cell sensitivity to intrinsic tolerance”
• The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “However, in the case of patients with autoimmune disorders, the mechanism to maintain selftolerance fails and the result is that the immune system mistakenly attacks and destroys healthy self-tissue.(6,7) Given the intimate interplay between gut microbiota and the host immune system, it is not surpr”
• Follicular B helper T cells in antibody responses and autoimmunity (2005, background): “, a considerable component of peripheral B-cell tolerance seems to be deferred to T cell”