CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

By X. Tai, M. Cowan, L. Feigenbaum, A. Singer. Nature Immunology, 2005

677 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2c4e13bf052e70a6c1f34e43b9d19b9629239867

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In Immunology

1. Alexander Y. Rudensky
2. T. Malek
3. Steven Z. Josefowicz
4. I. Castro
5. Li-Fan Lu
6. C. Lio
7. B. Beutler
8. C. Hsieh

Citations in the corpus

• Control of regulatory T cell lineage commitment and maintenance (2009, background): “Additionally, the lck-binding domain of the CD28 cytoplasmic tail is critical for the induction of Foxp3 (Tai et al., 2005), thereby suggesting a role for coordinated TCRCD28 signaling in thymic differentiation of Treg cells (Figure 1).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “CD28 recruits Lck and activates NF-κB, leading to tTreg cell development [45].”
• A two-step process for thymic regulatory T cell development. (2008, background): “It appears that the source of IL-2 is likely to be T cells themselves, because bone marrow chimeras with IL-2-deficient donors into wild-type hosts were phenotypically similar to that of IL-2-deficient mice (Tai et al., 2005).”
• Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Moreover, the lck-binding domain of the CD28 cytoplasmic tail is required for the induction of Foxp3 (67) and indicates a role for coordinated TCR-CD28 signaling during differentiation of Treg cells in the thymus.”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “As shown in Figure 2, developing thymocytes that received instructive TCR and CD28 signals developed into Treg cells after signaling through the IL-2R (Burchill et al., 2008; Lio and Hsieh, 2008; Tai et al., 2005).”
• Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. (2006, background): “For example, recent work has shown that CD28-mediated signals during thymic development are required for proper Foxp3 expression (29).”
• CD28 costimulation: from mechanism to therapy (2016, background): “(Tai et al., 2005) Thus, CD28 ligation directly supports Treg cell fate in the thymus and supports Treg survival and proliferation in the periphery.”