Cancerous stem cells can arise from pediatric brain tumors

By H. Hemmati, I. Nakano, J. Lazareff, M. Masterman-Smith, Daniel H. Geschwind, M. Bronner‐Fraser, H. Kornblum. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,913 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/615ff39b02955c79d61cf765b729754a03fdc404

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Citations in the corpus

A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations (2010, background): “The putative CSC marker CD133 (Hemmati et al., 2003) is expressed in all DTPs, but only in approximately 2% of the parental PC9 population (Figures 2A and 2B).”
Tissue repair and stem cell renewal in carcinogenesis (2004, background): “In addition, cells with some of the properties of neural stem cells (NSCs), such as the ability to produce differentiated neurons and glia in vitro and in vivo and enhanced renewal activity, have recently been isolated from brain tumours and brain-tumour-derived cell line”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Data to support a cancer stem cell concept for solid tumours have been reported (Al-Hajj et al., 2003; Hemmati et al., 2003; Passegué et al., 2003; Singh et al., 2003; Serakinci et al., 2004).”
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (2009, background): “We also noted an apparent lack of mRNA for prominin-1 (CD133).”
Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma (2004, background): “(17), when passage seventh medulloblastoma-derived cells were transplanted orthotopically, after 6 weeks from transplantation, no sign of tumor formation could be observed, and the transplanted cells did not migrate significantly from the graft (Fig.”
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “Nevertheless, nestin was one of the first markers of neural stem cells to be identified (46) and its expression has been shown in a subset of cells within neurospheres derived from primary human medulloblastoma, suggesting it marks stem-like cells in these tumors (32, 33).”
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. (2007, neutral): “cancer stem cells [2-6].”
Cancer stem cells in glioblastoma (2015, methodology): “A burst of studies soon followed describing brain CSCs in anaplastic astrocytoma (Ignatova et al. 2002), medulloblastoma, pilocytic astrocytoma, ependymoma, ganglioglioma (Hemmati et al. 2003; Singh et al. 2003), and GBM (Ignatova et al. 2002; Hemmati et al. 2003; Galli et al. 2004).”
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells (2013, background): “GBMs harbor a subpopulation of highly tumorigenic, stem-like cells (GSCs) (Dirks, 2010; Hemmati et al., 2003; Singh et al., 2004), and that GSCs are responsible for glioma propagation, resistance to conventional therapy, and tumor recurrence (Bao et al.”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Neurosphere (hereon termed tumor sphere)-forming cells isolated from medulloblastoma and glioma express the neural stem cell marker CD133 and exhibit the ability to self-renew and differentiate along divergent neuronal lines (Hemmati et al., 2003; Ignatova et al., 2002; Singh et al., 2003; Uchida et”
Cancer stem cells in nervous system tumors (2004, background): “Another recent report by Hemmati et al. (2003) substantiated the finding of cancer stem cells in pediatric brain tumors.”