Cancer stem cells in glioblastoma

By J. Lathia, S. Mack, Erin E Mulkearns-Hubert, C. Valentim, Jeremy N. Rich. Genes & Development, 2015

1,484 citations recorded by the source corpus.

Glioblastoma is the most prevalent and malignant primary brain tumor, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. In this review, Lathia et al. discuss how the integration of genetics, epigenetics, and metabolism has shaped our understanding of how CSCs function to drive GBM growth.

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/1282e67d1a1e77984b8ec87b107576e1d1e8f091

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Joyce
2. T. Hunter
3. D. Quail
4. I. Stamenkovic
5. R. Weinberg

In Genetics

1. T. Hunter
2. J. Joyce
3. D. Quail

In Oncology

1. J. Joyce
2. D. Quail
3. T. Hunter
4. Inder M. Verma
5. I. Stamenkovic
6. R. Weinberg
7. Zena Werb

Citations in the corpus

• An integrative model of cellular states, plasticity and genetics for glioblastoma (2019, positive): “Although various markers can enrich for putative GSCs (Lathia et al., 2015), it is unknownwhether different GSCmarkers isolate distinct or similar cellular states and whether tumors generated with different subpopulations of GSCs give rise to glioblastoma of comparable or diverse cellular…”
• The microenvironmental landscape of brain tumors (2017, result): “…cell pool (Calabrese et al., 2007; Charles and Holland, 2010; Charles et al., 2010; Gilbertson and Rich, 2007; Hambardzumyan et al., 2008; Lathia et al., 2010, 2015; Pietras et al., 2014), and similar results have been shown in the NSC-rich subventricular zone of normal brain tissue…”
• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma (2016, neutral): “The 100 candidate genes were then restricted to (1) genes that are positively correlated with both PC2 and PC3, which primarily excluded ribosomal protein genes that were only correlated with PC2; (2) genes for which the average relative expression among the stem-like cells was above average.”