Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
By Xing Fan, W. Matsui, L. Khaki, D. Stearns, J. Chun, Yue-Ming Li, C. Eberhart. Cancer Research, 2006
654 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/c029658e8657c09a9a4bdb67e0db3bce5789f6c2
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In Molecular Biology
In Oncology
- Jeremy N. Rich
- J. Lathia
- Eric C. Holland
- Anita B. Hjelmeland
- Angelo Luigi Vescovi
- Eric R. Fearon
- P. Dirks
Citations in the corpus
- MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, positive): “In a brain tumor model, inhibiting the Notch pathway indeed depleted CD133+ brain cancer stem cells and blocked tumor initiation [44], consistent with our findings in pancreatic cancer model.”
- Cancer stem cells in glioblastoma (2015, background): “The dependence of glioma CSCs on Notch signaling is further supported by experiments demonstrating depletion of CSCs by treatment with γ-secretase inhibitors (Fan et al. 2006, 2010).”
- Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Another γ-secretase inhibitor depletes tumour-initiating cells in brain tumour”
- Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, methodology): “Clonogenic assays were performed as previously described [ 57 ].”
- Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “GSCs activate a number of key stem cell signaling pathways, including Akt, bone morphogenetic protein, c-myc, hypoxia response, Notch, and Sonic Hedgehog (Bar et al., 2007; Eyler et al., 2008; Fan et al., 2006; Li et al., 2009; Piccirillo et al., 2006; Wang et al., 2008b).”
- Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma (2010, background): “Furthermore, increased Notch signalling enhances the efflux of cytotoxic drugs through ABC transporters such as ABCG2 , a recognized property of stem-like tumour cells that contributes to their resistance to conventional therapie”