HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.

By V. Clément, P. Sánchez, N. de Tribolet, I. Radovanovic, Ariel Ruiz i Altaba. Current Biology, 2007

1,110 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ebc172a2a1f7fe7f157e0497ec92d3ffa0ccc451

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Citations in the corpus

Cancer stem cells in glioblastoma (2015, background): “2013), GLI1 (Clement et al. 2007), ASCL1 (Rheinbay et al.”
The brain tumor microenvironment (2011, background): “Astrocytes also mediate activation of developmental pathways like the sonic hedgehog (SHH) pathway in the glioma PVN. SHH signaling is known to play an important role in BTSC self-renewal and growth of gliomas (Clement et al., 2007; Stecca and Ruiz i Altaba, 2005).”
Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells (2008, positive): “, 2007) and that treatment with Shh pathway inhibitors can suppress the growth of glioma cell lines and xenografts (Bar et al., 2007; Clement et al., 2007).”
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, result): “Clement et al. have recently reported findings similar to ours in several ways [ 50 ].”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “Furthermore, Sox2 is expressed in many neural brain tumor cells, particularly in the stem cell componen”
Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. (2008, methodology): “Glioblastoma-Derived Neurospheres Fresh glioblastoma tissue was dissociated in presence of papain and DNase I basically as described previously.(18) Cells were cultured under stem-cell conditions to form spheres using Dulbecco’s modified Eagle medium/F12 medium containing B27 supplement and 20 ng/mL”
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma (2008, positive): “2006), and roles in forebrain glioma have been reported (Clement et al., 2007; Ehtesham et al., 2007).”