Tissue repair and stem cell renewal in carcinogenesis

By P. Beachy, S. S. Karhadkar, David M. Berman. Nature, 2004

1,214 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4aa9d036017ea7ff3e3ebe1369ac54ed466d2f60

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Citations in the corpus

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors (2008, background): “These parallels have given rise to the hypothesis that tumors often arise from undifferentiated stem or progenitor cells or, alternatively, that cancer cells can undergo progressive de-differentiation during their developmen”
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing (2007, background): “We and others have suggested that stem and progenitor cells are especially at risk for cancer initiation owing to their continued expansion during states such as chronic wound healing and inflammatio”
Hepatocellular carcinoma pathogenesis: from genes to environment (2006, background): “, and inflammation seems to activate pathways that support tissue stem cell growt”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “In states of pancreatic inflammation or damage, an expanded “stem cell”-like compartment could represent a subpopulation of cells susceptible to oncogenic transformation upon somatic mutation of key proto-oncogenes and tumor suppressor genes (Beachy et al. 2004).”
The role of the Hedgehog signaling pathway in cancer: A comprehensive review. (2017, background): “in the maintenance of somatic stem cells and pluripotent cells important for tissue repair [3], such as mammary [4], skin [5], neural [6], erythropoietic [7], and lung stem cells [8], as well as some epithelial cells of internal organs [9].”
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells (2006, background): “Abnormal activation of both Wnt and Hedgehog signaling pathways has recently been implicated in PCa development and progression (Beachy et al., 2004; Yardy and Brewster, 2005).”
Module map of stem cell genes guides creation of epithelial cancer stem cells. (2008, background): “The stem cell model of tissue organization posits that a small number of progenitor cells maintains the self-renewal and organization of the tissue (reviewed by Beachy et al., 2004; Clarke and Fuller, 2006).”
Hedgehog Signaling in Development and Cancer (2008, neutral): “Recentstudies have alsoimplicatedHh signaling asessentialfor stemcellmainte-nance (Beachy et al., 2004).”
Epithelial stem cells: turning over new leaves. (2007, neutral): “Conversely, activating mutations of Shh signaling or inactivating mutations of its negative regulator (Patched) are found in familial and sporadic basal cell carcinomas, a frequent skin cancer, and in several other types of epithelial cancers including pancreatic carcinoma (Beachy et al., 2004).”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Although pathways that regulate self-renewal are tightly controlled in normal stem cells, in tumour-initiating cells they may be constitutively activated or improperly regulated through genetic and/or epigenetic changes, leading to uncontrolled growt”
Cancer metastasis: building a framework. (2006, background): “The Wnt/β-catenin, Hedgehog, and Notch signaling pathways are also implicated in stimulating self renewal in both normal stem cells and malignant cells (Beachy et al., 2004; Radtke and Clevers, 2005).”