Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

By Lei Liu, D. Feng, Guo Chen, Ming Chen, Q. Zheng, Pingping Song, Q. Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi and 11 more. Nature Cell Biology, 2012

1,569 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c306e1d5729dcc0d005fa51d0aa6e8366cf7513b

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Citations in the corpus

Autophagy in malignant transformation and cancer progression (2015, neutral): “As an increasing number of activities is being ascribed to these and other autophagy mediators (Cosse et al , 2010; Lee et al , 2012; Liu et al , 2012a; Moscat & Diaz-Meco, 2012; Zhao et al , 2012; Maskey et al , 2013; Elgendy et al , 2014), it remains possible that other, autophagy-independent…”
Metabolic regulation of mitochondrial dynamics (2016, background): “The dephosphorylation event promotes the interaction of FUNDC1 with ATG8 (also known as LC3), stimulating formation of the autophagic membrane (Liu et al., 2012; Chen et al., 2014).”
Cell Death Signaling. (2015, background): “NIX, a Bcl2-family-related protein, promotes removal of the entire mitochondrial pool during terminal erythrocyte differentiation (Schweers et al. 2007; Sandoval et al. 2008), and FUNDC1 participates in hypoxia-induced mitochondrial clearance (Liu et al. 2012).”
Ubiquitination and selective autophagy (2012, background): “(FUNDC1) was identified as a receptor for hypoxia-induced mitophagy by interacting with LC3 through a LIR motif.(86)”
Recent insights into the function of autophagy in cancer (2016, background): “These mitophagy adaptors interact directlywith processed LC3 and promote an overall reduction in mitochondrial mass as an adaptive response to stresses (Novak et al. 2010; Hanna et al. 2012; Liu et al. 2012; Chourasia et al. 2015a).”
Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, neutral): “, 2008), FUN14 domain containing 1 [FUNDC1] (Liu et al., 2012), BCL2 interacting protein 3 [BNIP3] (O'Sullivan et al.”
To be or not to be? How selective autophagy and cell death govern cell fate. (2014, neutral): “Another mitochondrial outer membrane protein, FUNDC1, may also be required for mitophagy through interaction with LC3 in a process regulated by hypoxia and FUNDC1 dephosphorylation (Liu et al., 2012).”