Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view.
By G. Twig, Brigham B. Hyde, Orian Shirihai. Biochimica et Biophysica Acta, 2008
658 citations recorded by the source corpus.
The mitochondrial life cycle consists of frequent fusion and fission events. Ample experimental and clinical data demonstrate that inhibition of either fusion or fission results in deterioration of mitochondrial bioenergetics. While fusion may benefit mitochondrial function by allowing the spreading of metabolites, protein and DNA throughout the network, the functional benefit of fission is not as intuitive. Remarkably, studies that track individual mitochondria through fusion and fission found that the two events are paired and that fusion triggers fission. On average each mitochondrion would go though approximately 5 fusion:fission cycles every hour. Measurement of Deltapsi(m) during single fusion and fission events demonstrates that fission may yield uneven daughter mitochondria where the depolarized daughter is less likely to become involved in a subsequent fusion and is more likely to be targeted by autophagy. Based on these observations we propose a mechanism by which the integration of mitochondrial fusion, fission and autophagy forms a quality maintenance mechanism. According to this hypothesis pairs of fusion and fission allow for the reorganization and sequestration of damaged mitochondrial components into daughter mitochondria that are segregated from the networking pool and then becoming eliminated by autophagy.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4e57cab807480565b188965e56202c625dbbae97
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In Clinical Biochemistry
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Citations in the corpus
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin (2010, background): “Refusion appears to be dependent upon the recovery of mitochondrial membrane potential after division and likely represents a mechanism to sort out terminally dysfunctional mitochondria (20).”
- The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Fission events were demonstrated to play a role in segregating dysfunctional mitochondria from the entire mitochondrial web (5, 30, 112) and to sort out mutant mtDNA copies (61, 103).”