Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.

By Alain R Simard, D. Soulet, G. Gowing, J. Julien, S. Rivest. Neuron, 2006

1,247 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/5e30be3cd03f5d06d58f8c0ba6931d3bec0bf5ec

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Citations in the corpus

Inflammation as a central mechanism in Alzheimer's disease (2018, background): “[115] Simard AR, Soulet D, Gowing G, Julien J-P, Rivest S.”
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease (2008, background): “It has been proposed that activated microglia clear amyloid deposits 13 , are the nidus for initiation of amyloid fibrils 14 or restrict plaques 15 .”
Regulation of innate immune responses in the brain (2009, background): “In support of the latter hypothesis, bone marrow-derived microglial cells have been shown to be closely associated with Aβ plaques and to slow the progression of the disease by removing Aβ from the CN”
The role of microglia in amyloid clearance from the AD brain (2010, background): “…cells allowed the demonstration that these cells could infiltrate the brain in a number of CNS disease models in which lethally irradiated hosts received adoptively transplanted fluorescent bone marrow cells (Kennedy and Abkowitz 1997; Malm et al. 2005; Simard and Rivest 2004; Simard et al. 2006).”
Microglial physiology: unique stimuli, specialized responses. (2009, neutral): “in removal of the amyloid material (107).”
Multi-modal techniques for diagnosis and prognosis of Alzheimer’s disease (2009, background): “This approach is relevant to Alzheimer's disease because perivascular macrophages and microglia derived from circulating monocytes may participate in intraparenchymal inflammation in the brai”
Inflammation in Alzheimer disease: driving force, bystander or beneficial response? (2006, background): “The authors transferred bone marrow cells from actin–green fluorescent protein (GFP) transgenic mice into irradiated young or old APP or wild-type mice and found more GFP-positive microglia in APP brains than in wild typ”
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration (2011, background): “Moreover, during CNS diseases, mononuclear phagocytes with morphological similarities to endogenous microglia can be derived from bone marrow cells or from circulating monocytes that subsequently become an integral part of the pathology and can be incorporated into the local cellular network”
Systemic infections and inflammation affect chronic neurodegeneration (2007, background): “and possible recruitment of monocytes from the bloo”
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “The semi-synthetic second generation tetracycline antibiotic derivative minocycline, which has antiinflammatory properties and readily crosses the BBB, has been investigated in rodent and non-human primate models of PD with mixed outcomes.”
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “, which include cellular maintenance (for example, clearing toxic cellular debri”