Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

By M. Block, L. Zecca, Jau-Shyong Hong. Nature Reviews Neuroscience, 2007

4,009 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/b9609598dee6678369796285e4e9d74033513333

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Citations in the corpus

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord (2009, background): “, matrix metalloproteinases (MMPs)], and nitric oxide, all of which are able to kill neurons and glia (Block et al., 2007).”
Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “…characterized by upregulation of inflammatory mediators such as Tnf (Tumor Necrosis Factor), Il1b (Interleukin 1 beta), and reactive oxygen species (see Block et al., 2007) to immunosuppressive ‘‘M2-like’’ phenotypes characterized by upregulation of Chil3 (Chitinase-like 3), Fzd1 (Frizzled class…”
Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications (2014, background): “glycosylphosphatidylinositol-anchored membrane glycoprotein), and other receptor-mediated pathways [119, 120].”
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. (2012, neutral): “Chronic microglial activation is considered to be the most damaging response of microglia to injury (Block et al., 2007).”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, neutral): “For example, microglia, the principal mediator of infl ammation in the CNS, release a large amount of ROS/RNS upon activation (Colton and Gilbert, 1987; Moss and Bates, 2001; Liu et al., 2002; Block et al., 2007), leading to OS increases and further neuronal damage.”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…al., 2003), inducible NO synthase (iNOS) (Possel et al., 2000, Lu et al., 2012), reactive oxygen and nitrogen species (ROS/RNS) (Qin et al., 2004, Block et al., 2007), and MCP-1/CCL2 (Kim et al., 2011), a chemokine involved in attracting peripheral immune cells into the brain (see Figure…”
Normal gut microbiota modulates brain development and behavior (2011, background): “Recent data indicate that pattern recognition receptors expressed on the microglia surface characterize one of the primary, common pathways by which neurotoxin signals affect neuronal tissues (34).”
Role of Microglia in Neurotrauma (2010, neutral): “to identify and react to noxious stimuli and harmful events.(10) Microglia also express receptors for a number of”
Microglial Activation & Chronic Neurodegeneration (2010, background): “Reactive microgliosis-chronic response to a single stimulus Although microglial activation was initially perceived as a transient event,(31) it is now believed to be chronic and culpable in the propagation of disease.(1,94,157) Reports have shown that microglia can remain chronically activated(140,1”