Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

By Marco Prinz, Josef Priller, Sangram S. Sisodia, R. Ransohoff. Nature Neuroscience, 2011

703 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/62827cda9ec1babf5c6420da0ce5b2c5c9512523

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In Immunology

In Neurology

Citations in the corpus

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing (2018, positive): “Microglia are brain parenchymal macrophages that are implicated in numerous neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, stroke, and brain tumors (Colonna and Butovsky, 2017; Prinz et al., 2011).”
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia (2013, background): “They react to different stimuli such as injury, neurodegeneration, stroke, or brain tumors (Prinz et al., 2011; Stoll and Jander, 1999; Streit, 2002).”
iPSC-derived human microglia-like cells to study neurological diseases (2017, neutral): “Many of these cytokines are known to be highly elevated in neurological diseases and/or involved in the recruitment of peripheral immune cells into the CNS under pathological conditions (Stalder et al., 2005, Prinz et al., 2011, Rezaie and Male, 1999, Chan et al., 2007).”
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways (2013, background): “Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.”
Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. (2015, background): “Chronic deposition of Aβ in brain drives cerebral neuroinflammation by activating microglia, which is reported to be a major source of proinflammatory cytokines in AD (38).”