Systemic infections and inflammation affect chronic neurodegeneration

By V. Perry, C. Cunningham, C. Holmes. Nature reviews. Immunology, 2007

1,027 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/3cb9c5e078e04f5c19f105b2137275f4d79dff9f

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Citations in the corpus

Microglia and neurodegeneration: The role of systemic inflammation (2013, methodology): “The terminology we adopted at that time (Perry et al., 2007) was derived from the original description of peripheral macrophage priming (Johnson et al.”
Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “Activation of the systemic innate immune system by infection may be involved in the early stages of AD pathogenesis (Perry et al., 2007).”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Investigators have proposed that the microglia in the prion diseased brain are primed by the ongoing pathology and that a secondary stimulus, the signaling of systemic inflammation across the BBB, switches these cells to an aggressive phenotype (98).”
Inflammation: The Common Pathway of Stress-Related Diseases (2017, background): “Activation of the systemic innate immune system by infection may participate in the early stages of AD pathogenesis (Perry et al., 2007).”
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease (2009, background): “Elderly, demented patients often have systemic comorbidities, such as pneumonia and other infections, and it has been shown that infectious disease outside the CNS can profoundly influence microglial activation [23, 27, 36].”
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “Moreover, in addition to the neuroinflammation found in many neurodegenerative disorders, systemic inflammation may further exacerbate the progression of neurodegeneration (Perry et al. 2007).”
Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “Such microglial responses were seen in a mouse model of prion disease challenged with inoculation with LP”
Differential roles of microglia and monocytes in the inflamed central nervous system (2014, background): “Despite this apparent uniformity, gene expression by morphologically identical microglia can differ drastically contingent on context (Perry et al., 2007).”
Regulation of learning and memory by meningeal immunity: a key role for IL-4 (2010, background): “Innate immune cells, both peripheral and CNS resident, were proposed as the source of proinflammatory cytokines that are secreted in response to any deviation from physiological homeostasis as a result of stress, disease, or injury (Perry et al., 2007).”
A meta-analysis of cytokines in Alzheimer's disease. (2010, background): “Thereore, over time, it has been suggested that the net effect of icroglial activation might be to further increase amyloid- depoition, perpetuating the neurodegenerative cascade (19,151).”