Microglial physiology: unique stimuli, specialized responses.

By R. Ransohoff, V. Perry. Annual Review of Immunology, 2009

1,815 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/310278f19db789cdf662cd5a5ccad60d054156a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. B. Barres
2. Beth Stevens
3. R. Ransohoff
4. Xia Zhang
5. Wei-Wei Chen
6. Wenjuan Huang
7. G. Harry
8. C. McPherson

In Neurology

1. R. Ransohoff
2. B. Barres
3. Beth Stevens
4. Xia Zhang
5. Wei-Wei Chen
6. Wenjuan Huang
7. Melinda E Lull
8. G. Harry

Citations in the corpus

• Microglial Activation & Chronic Neurodegeneration (2010, background): “Thus, evidence supports that when microglia become neurotoxic, this is due to both the loss of the beneficial functions(36) and/or a shift to a pro-inflammatory phenotype.(1,45,46)”
• Role of neuroinflammation in neurodegenerative diseases (Review) (2016, positive): “Immune activation in the CNS, always present in viral infections, immune‑mediated disorders, and neurodegenerative diseases (11), involves microglia and astrocytes (12) which constitute the resident immune cells of the CNS and play an important role in the regulation of homeostasis of the brain…”
• The role of microglia in amyloid clearance from the AD brain (2010, background): “However, whether peripheral myeloid cells can infiltrate the diseased brain remains controversial and will be discussed in the next section (Hess et al. 2004; Nakajima and Kohsaka 2001; Priller et al. 2001; Ransohoff and Perry 2009).”
• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Several mechanisms by which these cells maintain a quiescent state have been proposed, including interaction of microglial CX3CR1 receptor with its neuronal ligand the chemokine CX3CL1 and inhibitory signalling through the microglial cell surface proteins CD172, CD200R and CD45 with their neuronal l”
• The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “Microglia, the resident phagocytes of the CNS, are the only resident brain cells to express CR3 (Tenner & Frank 1987, Guillemin & Brew 2004, Ransohoff & Perry 2009, Graeber 2010 ).”
• Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro (2013, methodology): “…France d Perinatal Centre, Institute of Neuroscience and Physiology and Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden e Department of Reproductive Biology, Imperial College London, United Kingdom f Centre for the Developing Brain, Department of Perinatal…”
• Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation (2016, positive): “Microglia are innate immune cells that repair injury and maintain homeostasis in the CNS (Ransohoff and Perry, 2009).”
• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “They continuously survey the brain parenchyma to detect any alterations in their microenvironment.(302,304,305) Since it can reduce inflammation, it is beneficial for dead and dying neurons to undergo phagocytosis.”