Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

By Melanie Meyer‐Luehmann, T. Spires-Jones, Claudia M. Prada, M. Garcia-Alloza, A. Calignon, Anete Rozkalne, J. Koenigsknecht-Talboo, D. Holtzman, B. Bacskai, Bradley T. Hyman. Nature, 2008

889 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/2757976db62535cc055b197e975a997b2ed00e58

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. Helene Benveniste
2. John Hardy
3. Mark J. Schnitzer

In Neurology

1. M. Schwartz
2. Robin J. M. Franklin
3. Nora D. Volkow
4. John Hardy
5. David A. Bennett
6. Carol A. Colton
7. Wolfgang Becker
8. C. Iadecola

In Physiology

1. Helene Benveniste
2. John Hardy
3. Nora D. Volkow
4. Bradley T. Hyman
5. David A. Bennett
6. Carol A. Colton
7. E. Latz
8. A. Ljubimov

Citations in the corpus

• Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy (2011, positive): “There are already a large set of fluorescent markers of pertinence to disease studies, such as labels for amyloid plaques 10 , reactive oxygen species 9 , and glia and immune cells 11 , and many of these should be readily usable in combination with microendoscopy.”
• Debris clearance by microglia: an essential link between degeneration and regeneration (2008, background): “Recently, it was shown by in vivo two-photon microscopy that not only the processes, but also the cell bodies of microglial cells are activated and recruited to newly formed amyloid-b (Ab) plaques within 1–2 days in an animal model of Alzheimer’s disease (Meyer-Luehmann et al., 2008).”
• Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease (2013, background): “Close association and positive feedback between amyloid-b and microglia (Meyer-Luehmann et al., 2008) further cloud the cause and effect relationships of inflammation to disease progression.”
• β-Amyloid accumulation in the human brain after one night of sleep deprivation (2018, background): “It has been shown in rodents that Aβ plaques can form very rapidly (41), while Aβ plaques in their earliest stages show the highest levels of neuritic dystrophy (42), thus suggesting that increases in ABB due to one-night SD could adversely impact the brain.”
• The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal (2009, background): “which induces glial and neuritic changes (Meyer-Luehmann et al. 2008) but the only time that substantial Ab induced”
• Identification of Amyloid Plaques in Retinas from Alzheimer’s Patients and Noninvasive In Vivo Optical Imaging of Retinal Plaques in a Mouse Model (2010, positive): “Optical detection constitutes a powerful, high-resolution and specific tool for in vivo imaging (Fujimoto and Farkas, 2009), as demonstrated using multiphoton microscopy to detect Aβ plaques in the mouse brain via an invasive cranial window (Meyer-Luehmann et al., 2008).”
• Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks (2008, positive): “We have recently shown that plaques induce neuritic dystrophies within a radius of ~25 microns, similar to the region noted to have neurites with an increased chance of elevated [Ca]i (Meyer-Luehmann et al., 2008).”