Inflammation as a central mechanism in Alzheimer's disease
By J. Kinney, S. Bemiller, A. Murtishaw, Amanda M. Leisgang, A. Salazar, B. Lamb. Alzheimer's & Dementia, 2018
1,929 citations recorded by the source corpus.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.
Subfields: Biological Psychiatry, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/5aaf380a632942d41ec50bac49abb001dfc393ca
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In Physiology
Citations in the corpus
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019, neutral): “Direct microglial effects on neuron viability—Activated microglia can directly secrete toxic proinflammatory cytokines (Colonna and Butovsky, 2017; Kinney et al., 2018) or secrete indirect mediators that stimulate astrocytes to secrete a neurotoxic substance (Liddelow et al.”
- Role of neuroinflammation in neurodegeneration development (2023, background): “Numerous cytokines and chemokines have been shown to contribute to the pathogenesis of neurodegenerative diseases as summarized by the recent reviews.(9,253,412) In addition to cytokines and chemokines, bioactive lipids also play crucial role during all phases of the innate immune responses.”
- Nanomedicine-Driven Modulation of the Gut–Brain Axis: Innovative Approaches to Managing Chronic Inflammation in Alzheimer’s and Parkinson’s Disease (2025, unknown): “In AD and PD, the persistent activation of innate immunity inside the brain results in progressive neuronal injury and impaired synaptic transmission, culminating in cognitive and motor deficits [5].”