Ink4a/Arf expression is a biomarker of aging.

By J. Krishnamurthy, C. Torrice, M. R. Ramsey, G. Kovalev, Khalid Al-Regaiey, L. Su, N. Sharpless. Journal of Clinical Investigation, 2004

1,534 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5b25e72d000d08a468fd5e9b4a1b4c8009757274

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In Cancer Research

1. J. Campisi
2. M. Blasco
3. Manuel Serrano
4. M. Collado
5. R. DePinho
6. Jesús Gil
7. P. Jat
8. R. Kumari

In Molecular Biology

1. J. Campisi
2. M. Demaria
3. Jesús Gil
4. Manuel Serrano
5. N. Sharpless
6. R. DePinho
7. S. Morrison
8. M. Blasco

In Physiology

1. J. Campisi
2. J. Kirkland
3. M. Demaria
4. Jesús Gil
5. T. Tchkonia
6. Manuel Serrano
7. Adam Freund
8. P. Jat

Citations in the corpus

• Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “
 
 
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 co-regulated in mouse (Krishnamurthy et al., 2004; Zindy et al., 1997), co-regulation of the two genes in human cells is not well established.”
• Cellular senescence promotes adverse effects of chemotherapy and cancer relapse (2016, background): “Expression of the tumor suppressor p16INK4a increases with age and is a robust senescence marker in numerous mouse and human tissues (13, 14).”
• Cellular Senescence: A Translational Perspective (2017, background): “In a key study, caloric restriction, an invention that increases maximum lifespan in mice, was associated with decreased p16 and SA-βgal cell abundance in mice (Krishnamurthy et al., 2004).”
• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Senescent cells express ligands for cytotoxic immune cells, such as natural killer (NK) cells, and have been shown to be able to be specifically eliminated by the immune system (123, 124).”
• DNA damage response and cellular senescence in tissues of aging mice (2009, methodology): “…as well in postmitotic tissues like heart or brain ª 2009 The Authors Journal compilation ª Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2009 (Melk et al., 2003; Krishnamurthy et al., 2004) casts some doubt on its suitability as a sole marker for cell senescence.”
• Stems cells and the pathways to aging and cancer. (2008, background): “Elevated expression of the Rb effector p16Ink4a has been demonstrated in numerous tissues with age (Krishnamurthy et al., 2004; Zindy et al., 1997) and has emerged, along with senescence-associated b-galactosidase activity (SAb-gal) (Dimri et al., 1995), as one of the principal biomarkers of aging.”
• Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, background): “40 times higher than that of any ANRIL exon, even though brain expresses low levels of p16 [44,46].”
• Causes, consequences, and reversal of immune system aging. (2013, positive): “and ARF also occurs in aging cells from multiple tissues (79, 80).”
• Senescent cells as a source of inflammatory factors for tumor progression (2010, background): “Senescent cells are detected in culture and in vivo by a variety of markers, including the senescence-associated β-galactosidase (SAβgal) [28], p16 [39], telomere-associated DNA damage foci [40], senescence-associated heterochromatin foci [41], and several other molecules; all of these markers have ”
• The regulation of INK4/ARF in cancer and aging. (2006, positive): “These experiments were motivated by the seminal observation of Sherr and colleagues (Zindy et al., 1997), later confirmed by several groups (Krishnamurthy et al., 2004; Melk et al., 2004; Nielsen et al., 1999), that the expression of p16 INK4a increases markedly with aging in many tissues of…”
• Fisetin is a senotherapeutic that extends health and lifespan (2018, background): “For example, senescent cells accumulate with age and at sites of pathogenesis in chronic diseases [5,70].”