Causes, consequences, and reversal of immune system aging.

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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 (2020, positive): “Given the results here, it is tempting to speculate that an already restricted immune response in the aging population prevents successful inhibition of viral spread at early stages of infection, further exacerbating the morbidity and mortality observed for this age group (Jing et al., 2009; Monteci”
The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “185,186), implies increased vulnerability to developing diseases such as osteoarthritis 187 , rheumatoid arthritis and cardiovascular diseases 188 .”
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity (2020, background): “Advanced age is a dominant risk factor for severe COVID-19 and is correlated with reduced immune function (20).”