The regulation of INK4/ARF in cancer and aging.

By William Y. Kim, N. Sharpless. Cell, 2006

1,023 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ba5b74f554c94a0e46671688be784bc507bfdab0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Campisi
2. Manuel Serrano
3. M. Blasco
4. M. Collado
5. Jesús Gil
6. P. Jat
7. R. Kumari
8. Zefeng Wang

In Immunology

1. J. Campisi
2. Jesús Gil
3. Manuel Serrano
4. N. Sharpless
5. M. Blasco
6. M. Collado
7. P. Jat
8. R. Kumari

In Molecular Biology

1. J. Campisi
2. Jesús Gil
3. K. Helin
4. Manuel Serrano
5. A. Bracken
6. Domhnall McHugh
7. F. d’Adda di Fagagna
8. P. Jat

Citations in the corpus

• Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Given this unusual concentration of three tumor suppressors in barely 35 kb, this locus plays a key regulatory role and is frequently mutated in cancer (Gil and Peters, 2006; Kim and Sharpless, 2006).”
• Aging, Cellular Senescence, and Cancer (2012, background): “many senescent cells, is both a tumor suppressor and a biomarker of aging (64, 65).”
• Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, background): “…gene cluster occupies a 42 kb stretch on the human chromosome 9p21 and is homozygously deleted or expression silenced in a wide range of human cancers with an estimated frequency of ~40% (Sherr, 1998; Kim and Sharpless, 2006), representing one of the most frequently altered genes in human cancer.”
• Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, neutral): “Also, humans with biallelic p16 mutations are not predisposed to develop MRT (Kim and Sharpless, 2006; Roberts and Biegel, 2009).”
• The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm (2008, background): “The LD block with rs10757278 contains two known genes, CDKN2A and CDKN2B , which are known to have critical roles in cell proliferation, aging, senescence and apoptosi”
• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. (2007, result): “This would be consistent with the recent hypothesis that the all three genes are coordinately regulated (Gil and Peters 2006; Kim and Sharpless 2006).”
• Cellular senescence: when bad things happen to good cells (2007, background): “, and there is also mounting — but still largely circumstantial — evidence that cellular senescence promotes agein”
• Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, background): “restraining aberrant proliferation associated with cancer and other disease states (reviewed in: [15]).”