Stems cells and the pathways to aging and cancer.

By Derrick J. Rossi, Catriona H. M. Jamieson, Irving L. Weissman. 2008

910 citations recorded by the source corpus.

Subfields: Aging, Developmental Neuroscience, Physiology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In contrast, aging leads to a significant reduction in cell proliferation in both adult SGZ and SVZ (reviewed by Rossi et al., 2008).”
Programmed Cell Death in Animal Development and Disease (2011, neutral): “The combined consequence of their longevity and proliferation potential enables the propagation of these mutations to downstream progeny in a manner that could lead to oncogenesis (Rossi et al., 2008).”
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Such error-prone repair may contribute to stem cell senescence, apoptosis, and leukemic transformation (Rossi et al., 2007, 2008).”
Mechanisms of stem cell self-renewal. (2009, background): “Moreover, the accumulation of genetic damage in stem cells likely contributes to increased cancer incidence during aging (Rossi et al. 2008, Sharpless & DePinho 2007).”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Importantly, the number of hematopoietic stem cells does not decline with age (Morrison and Spradling, 2008; Rossi et al., 2008).”
Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010, positive): “This continuous self-renewal capacity is maintained by reservoirs of somatic tissue stem cell”
The hallmarks of aging. (2013, background): “This is especially relevant when DNA damage impacts the functional competence of stem cells, thus compromising their role in tissue renewal (Jones and Rando, 2011; Rossi et al., 2008) (see ‘‘Stem Cell Exhaustion’’).”
Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “Particularly, mitochondria are thought to play an important role in the pathogenesis of age-associated neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.”
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion (2010, background): “This change in lineage commitment is believed to contribute to the decline of the adaptive immune system with age, andat the same time,provides a cellular rationale basedon stemcell biology for the predisposition to myelogenous diseases in the elderly, and lymphoid malignancies in the young (15).”