An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

By G. Eberl, Shana Marmon, M. Sunshine, P. Rennert, Yongwon Choi, Dan R. Littman. Nature Immunology, 2004

994 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/531fe6a446e6d33b8df2a6cec58c687213682c84

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Dan R. Littman
2. K. Honda
3. D. Artis
4. A. Jetten
5. D. Cua
6. R. Medzhitov
7. H. Spits
8. Shimon Sakaguchi

In Oncology

1. R. Medzhitov
2. Dan R. Littman
3. K. Honda
4. yang-xin fu
5. D. Levy
6. W. Leonard
7. Shimon Sakaguchi
8. A. Jetten

In Pathology and Forensic Medicine

1. Dan R. Littman
2. R. Medzhitov
3. D. Cua
4. C. Tato
5. C. Weaver
6. F. Powrie
7. Paul R. Mangan
8. H. Spits

Citations in the corpus

• The Microbiome in Infectious Disease and Inflammation (2012, positive): “LTi cells require the helix-loop-helix inhibitor Id2 and RORγt for their development and IL-7 for their expression of LT-α and LT-β (193, 194).”
• RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota (2011, neutral): “, IL-22 + NKp46 + or NKp44 + cells and LTi cell”
• The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. (2012, neutral): “The prototypic ILC population, lymphoid tissue inducer (LTi) cells, is instrumental for the formation of secondary lymphoid organs during embryonic development and depends on the transcription factor RORgt (Eberl et al., 2004).”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, positive): “These models can be experimentally probed in cell transfer experiments employing donor cells from mice with a reporter gene (EGFP) knocked into the Rorc locus (encoding RORgt) (Eberl et al., 2004).”
• IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “To examine the role of RORγt in T cell development and lymphoid organogenesis, Littman and colleagues generated mice with the coding sequence for green florescent protein (GFP) knocked into the initiation site of RORγt translation, thereby reporting cells activating this locus while knocking out exp”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…functions as a positive regulator of Bcl-XL expression and, as a result, promotes the survival of DP thymocytes, thereby enabling gene rearrangement [Eberl et al., 2004; He et al., 1998; Jetten, 2004; Jetten and Joo, 2006; Jetten et al., 2001; Jetten and Ueda, 2002; Kurebayashi et al., 2000; Ma et…”
• Lymphoid organ development: from ontogeny to neogenesis (2006, background): “This unique subset of hematopoietic cells, derived from a fetal liver progenito”
• The microbiota regulates type 2 immunity through RORγt+ T cells (2015, background): “RORγt-deficient mice (14) were backcrossed at least 8 generations to a C57BL/6 background.”
• CD4+ lymphoid tissue inducer cells promote innate immunity in the gut (2010, background): “…in promoting innate immunity and intestinal inflammation via production of host protective and/or inflammatory cytokines (Buonocore et al., 2010; Cella et al., 2009; Colonna, 2009; Cua and Tato, 2010; Eberl et al., 2004; Satoh-Takayama et al., 2008; Sawa et al., 2010; Spits and Di Santo, 2010).”
• Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. (2014, background): “RORgt is a transcription factor required for ILC3 development (Eberl et al., 2004).”
• Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “We have expanded our analysis of IL-17-producing cells by examining expression of intracellular IL-17 or GFP in cells obtained from additional tissues of wild-type mice and mice heterozygous for insertion of GFP in the locus encoding RORgt, a transcription factor required for Th17 celldifferentiatio”
• Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, positive): “Because B-2 cell IgA production can mask the contribution of B-1 cells, we crossed Mac-Gata6 KO mice to Rorc-deficient (Rorc) mice, which lack secondary lymphoid organs (Eberl et al., 2004).”