The microbiota regulates type 2 immunity through RORγt+ T cells

By C. Ohnmacht, Joo‐Hong Park, Sascha Cording, J. Wing, K. Atarashi, Yuuki Obata, V. Gaboriau-Routhiau, R. Marques, S. Dulauroy, M. Fedoseeva and 8 more. Science, 2015

764 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/961e7c7b97c2c45661be3f571a4d69c562ae129b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Atsushi Tanaka
2. Naganari Ohkura
3. J. Wing
4. I. Zilber-Rosenberg
5. K. Ichiyama
6. N. Mikami
7. Eugene Rosenberg
8. Scott F. Gilbert

In Infectious Diseases

1. I. Zilber-Rosenberg
2. Eugene Rosenberg
3. Scott F. Gilbert

In Molecular Biology

1. I. Zilber-Rosenberg
2. Eugene Rosenberg
3. Scott F. Gilbert
4. J. Durack
5. S. Lynch
6. Elisabeth A. Lloyd

Citations in the corpus

• Regulatory T Cells and Human Disease. (2020, background): “In contrast, RORγt+Helios− Tregs are pTregs induced by the presence of intestinal microbiota, and the loss of RORγt expression by Tregs results in severe intestinal inflammation (86, 87).”
• Holobionts as Units of Selection and a Model of Their Population Dynamics and Evolution (2018, background): “2013) as well as for inducing the specific lymphocyte populations that balance the immune response at mucosal surfaces (Ohnmacht et al. 2015).”
• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Additionally, GF animals possess fewer T reg cells (Atarashi et al., 2011; Ohnmacht et al., 2015), lack regulatory gut CD4+CD8αα+ double-positive intra-epithelial lymphocytes (Cervantes-Barragan et al., 2017), have compromised innate lymphoid cell function (Hepworth et al., 2013), and are more…”
• Impact of Omega-3 Fatty Acids on the Gut Microbiota (2017, background): “Early exposure to microbes in the intestine could be a critical factor modulating the original Th2-biased immune response, to subsequently induce the differentiation of other Th cell lineages, such as Th1, Th17, and Treg cells [31].”
• Homeostatic immunity and the microbiota (2017, neutral): “Notably, peripherally-induced Treg cells are reduced under germ free conditions (Geuking et al., 2011; Ohnmacht et al., 2015; Sefik et al., 2015; Yang et al., 2016).”