A microRNA array reveals extensive regulation of microRNAs during brain development.

By Anna M. Krichevsky, Kevin S. King, C. Donahue, K. Khrapko, Kenneth S. Kosik. RNA: A publication of the RNA Society, 2003

1,065 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/52fa362522f746069ae3d18d6c98e901c6cbcaf9

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Citations in the corpus

Regulation of miRNA expression during neural cell specification (2005, background): “A complete description of miRNA expression during stem cell differentiation will require the application of array technology (Krichevsky et al., 2003; Liu et al., 2004).”
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP (2008, background): “Interestingly, a significant fraction of miRNAs are enriched or specifically expressed in the nervous system (8), and transcription of some miRNAs changes dynamically during brain development (9, 10).”
Microarray-based, high-throughput gene expression profiling of microRNAs (2004, background): “Earlier attempts at systematic gene expression analysis have involved dot blot”
Human embryonic stem cells express a unique set of microRNAs. (2004, background): “The expression of miRNAs is often regulated in tissuespecific and developmental stage-specific manners (Aravin et al., 2003; Krichevsky et al., 2003; Lagos-Quintana et al., 2002; Pasquinelli et al., 2000; Sempere et al., 2003), although the regulatory mechanism is still largely unknown.”
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. (2004, background): “The development of array technology for the systematic analysis of miRNA expression profiles may help to overcome these limitations (Krichevsky et al. 2003).”
MicroRNA expression profiling in prostate cancer. (2007, methodology): “RNA extraction, labeling, and hybridization were done essentially as described previously ( 36 ).”
The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation (2006, background): “In lower organisms, miRNAs are essential for cell differentiation during developmen”
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, positive): “Expression of miR-9 is necessary for neurogenesis in cultured stem cells and its downregulated expression in presenilin-1 knockout mice correlates with premature cortical differentiation during embryogenesis [36,37, 57].”
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007, background): “Although a number of miRNAs are expressed in the NS (Kim et al., 2004; Krichevsky et al., 2003; Miska et al., 2004; Sempere et al., 2004), relatively little is known about their functions (Ashraf et al.”
The neuronal microRNA system (2006, background): “The nervous system is a rich source of miRNA expressio”
Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. (2008, background): “Although the small size of miRNA (17–25 nucleotides [nt]) creates challenges for their detection, recent innovative adaptations of existing technologies for gene expression profiling, such as microarrays and quantitative RT-PCR (qRT-PCR), have emerged that make large-scale characterizations of miRNA”