The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation
By I. Naguibneva, Maya Ameyar-Zazoua, A. Polesskaya, S. Ait-Si-Ali, R. Groisman, Mouloud Souidi, S. Cuvellier, A. Harel-Bellan. Nature Cell Biology, 2006
607 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/515e4c6b38547639669c6988332b3214f01ea82b
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In Cancer Research
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In Molecular Biology
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Citations in the corpus
- MicroRNAs in development and disease. (2011, background): “In addition, upregulation of miR-181 promotes differentiation by suppressing a MyoD negative regulator, HoxA11 (439), while downregulation of miR221/222 derepresses p27, inhibiting proliferation (75).”
- Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “It was primarily acknowledged that miRNAs result in gene expression repression at both the level of mRNA stability by conducting mRNA degradation and the level of translation (at initiation and after initiation) by inhibiting protein translation or degrading the polypeptides through binding…”
- The Role of MicroRNAs in Human Diseases (2010, background): “regulatory roles include neuronal gene expression ((45)), brain morphogenesis ((46)), muscle differentiation ((47)), and stem cell division ((48)).”
- MicroRNAs: new regulators of immune cell development and function (2008, background): “A nonhematopoietic developmental function for miR-181a, as well as a second isoform, miR-1816, in myoblast differentiation has also been describe”
- The neuronal microRNA system (2006, background): “In this case, miR-181 functions as a negative regulator of Hoxa11 to prevent the expression of the muscle determination gene MyoD and proteins further downstream such as myogenin and other muscle marker protein”
- Non-coding RNA. (2006, background): “The expression of many miRNAs is regulated and miRNAs have been shown to be central to a wide range of developmental processes, including developmental timing, cell proliferation, left–right patterning, neuronal cell fate, apoptosis and fat metabolism [for reviews see (8,133–135,143)], as well as ne”