The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.

By E. Makeyev, Jiangwen Zhang, M. Carrasco, T. Maniatis. Molecules and Cells, 2007

1,403 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/969c7cea592d65b584f41ec100ca1a23d5c4c5e1

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Citations in the corpus

MicroRNAs in development and disease. (2011, background): “miR-124 also exerts its function by inducing an alternative splicing pattern of genes that is characteristic of neurons (401).”
The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, background): “Given their essential role in modulation of cellular processes such as cell fate, identity, and function (Sempere et al., 2004; Kim et al., 2007; Makeyev et al., 2007), we screened a panel of predicted REST-regulated miRNAs (Jothi et al.”
Biological functions of microRNAs: a review (2011, background): “Thus, miR-124 promotes NS development, at least in part by regulating an intricate network of NS-specific alternative splicing [ 32 , 51, 65].”
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells (2009, neutral): “A total of 2,563 CLIP-seq reads were mapped to the polypyrimidine tract binding protein 2 ( nPTB ) gene, which is crucial for many regulated splicing events in neuron”
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. (2008, background): “Another down-regulated miR in glioblastoma (miR-124) plays a direct role in promoting neuronal differentiation ( 20 ), suggesting that the coordinated action of multiple miRs is vital in the maintenance of undifferentiated glioma stem-like cells.”
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “Like hnRNP A/B proteins, PTB is expressed throughout development, then downregulated in many adult tissues, most notably brain and muscle (Boutz et al. 2007a; Makeyev et al. 2007).”
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment (2008, result): “Our results are consistent with the finding that mir-124 is first expressed after neuronal commitment in the embryonic central nervous syste”
Non-coding RNAs as regulators of embryogenesis (2011, background): “In addition, miR-124 promotes neural-specific alternative splicing through the neural variant of the global repressor of alternative splicing polypyrimidine tract-binding protein 1 (PTB; neural variant, nPTB”
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2010, positive): “We found that miR-124, the most abundant brain-specific miRNA that regulates neuronal differentiation during CNS development and adult neurogenesi”
Functional consequences of developmentally regulated alternative splicing (2011, background): “Neural-specific expression of nPTB is due to silencing of PTB by a neuronal-enriched microRNA (miRNA), miR-124 (Ref”
Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. (2008, background): “…(Srinivasan et al. 2005; Boutz et al. 2007; Calarco et al. 2007; Ip et al. 2007; Ni et al. 2007), as well as detection of the global impact of specific splicing factors or environmental stimuli on splicing regulation (Park et al. 2004; Hung et al. 2007; Makeyev et al. 2007; Pleiss et al. 2007a,b).”