Regulation of miRNA expression during neural cell specification

By L. Smirnova, Anja Gräfe, A. Seiler, Stefan Schumacher, Robert Nitsch, F. Wulczyn. European Journal of Neuroscience, 2005

713 citations recorded by the source corpus.

Subfields: Aging, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b52f368aca55361984942abe06a96c3ae5bd58b

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Citations in the corpus

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. (2008, background): “miR-128 is enriched in brain ( 16 ), but its function is not known.”
Biological functions of microRNAs: a review (2011, background): “A role for miR-133b in this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion has been demonstrated [ 50 ].”
MicroRNAs: key regulators of stem cells (2009, background): “pl?acc=MI0000079">miR-23 are preferentially and specifically expressed in astrocyte lineages respectivel”
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007, background): “In human and mouse, this miRNA is encoded by three distinct genes (Conaco et al., 2006; Deo et al., 2006). miR-124 is expressed in neurons, but not astrocytes, and the levels of miR-124 increase over time in the developing NS (Krichevsky et al., 2003; Miska et al., 2004; Smirnova et al., 2005).”
The neuronal microRNA system (2006, background): “The validity of the stem cell model for studying miRNA regulation in neural development was recently confirmed and extended to include additional miRNA”
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2010, neutral): “1 ), the cells expressing the highest miR-124 level”
MicroRNAs in development and disease. (2011, background): “miR125 is also one of the miRNAs that is highly expressed in the brain and has a similar expression pattern as miR-9 during the development of the mouse brain (567).”
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment (2008, background): “Both mir-124 and mir-128 are restricted to neuron”
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008, result): “5E), which is consistent with previous observations (29).”
The Role of MicroRNAs in Human Diseases (2010, background): “Studies (105) have shown that some miRNAs are differentially expressed in neuronal nuclei, and/or different cell populations in brain (106) .”
Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis (2006, positive): “Since miR-124a is expressed preferentially in embryonic neurons, whereas miR-9 is expressed in both neurons and glia ([ 37 ] and our unpublished data), our results suggest that early overexpression of miR-124a in NPs prevents gliogenesis, whereas miR-9 expression contributes to neurogenesis.”
Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood (2014, background): “In addition, miR-126 (25), miR-191 (26) and miR-26 (27) have been implicated in the mouse brain through regulation of various neuronal proteins such as brain derived neurotropic factor and amyloid precursor protein.”