MicroRNA expression profiling in prostate cancer.

By Kati P. Porkka, Minja J. Pfeiffer, Kati K. Waltering, R. Vessella, T. Tammela, T. Visakorpi. Cancer Research, 2007

938 citations recorded by the source corpus.

MicroRNAs (miRNA) are small, endogenously expressed noncoding RNAs that negatively regulate expression of protein-coding genes at the translational level. Accumulating evidence, such as aberrant expression of miRNAs, suggests that they are involved in the development of cancer. They have been identified in various tumor types, showing that different sets of miRNAs are usually deregulated in different cancers. To identify the miRNA signature specific for prostate cancer, miRNA expression profiling of 6 prostate cancer cell lines, 9 prostate cancer xenografts samples, 4 benign prostatic hyperplasia (BPH), and 9 prostate carcinoma samples was carried out by using an oligonucleotide array hybridization method. Differential expression of 51 individual miRNAs between benign tumors and carcinoma tumors was detected, 37 of them showing down-regulation and 14 up-regulation in carcinoma samples, thus identifying those miRNAs that could be significant in prostate cancer development and/or growth. There was a significant trend (P=0.029) between the expression of miRNAs and miRNA locus copy number determined by array comparative genomic hybridization, indicating that genetic aberrations may target miRNAs. Hierarchical clustering of the tumor samples by their miRNA expression accurately separated the carcinomas from the BPH samples and also further classified the carcinoma tumors according to their androgen dependence (hormone naive versus hormone refractory), indicating the potential of miRNAs as a novel diagnostic and prognostic tool for prostate cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8296fe4c87a6b4f5e8459a44950def3c984fb558

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Citations in the corpus

Circulating microRNAs as stable blood-based markers for cancer detection (2008, background): “We established a list of likely blood-based miRNA biomarker candidates for prostate cancer by (i) compiling a list of miRNAs expressed in human prostate cancer specimens based on published miRNA expression profiling data (7, 18) and (ii) filtering out miRNAs detected in healthy donor-derived plasma ”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “Other studies explored microRNA expression in prostate cancer (19, 20).”
MicroRNAs and complex diseases: from experimental results to computational models (2019, neutral): “Especially, accumulated studies have shown that miRNAs can function as oncogenes or tumor suppressors in the initiation, progression and metastasis of various types of cancers [98], including breast cancer [95], prostate cancer [99], lung cancer [100], colon cancer [101], ovarian cancer [102].”
Identifying miRNAs, targets and functions (2012, background): “ported differentially regulated miRNAs in diverse cancer types, such as breast cancer [5], lung cancer [6], prostate cancer [7], colon cancer [8], ovarian cancer [9] and head and neck cancer [10].”
MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. (2008, background): “Many miRNAs are expressed in a tissue-specific manner and exhibitexpressionprofilesthataredifferentbetweennormaland neoplastic tissues and between tumors with distinct biological properties (6, 9, 10 ).”
MicroRNAs in development and disease. (2011, background): “miRNAs profiling of prostate tumors uncovered the dysregulation of some of the usual culprits, including downregulation of let-7, miR-145, miR-141, miR-125, miR-1, miR-133, miR106b, and miR-16 (12, 466, 491).”
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, background): “These approaches feature good reproducibility and facilitate clustering of samples by similar miRNA expression profiles (Davison et al. 2006; Porkka et al. 2007).”
Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma (2009, background): “S3).(11,13) Four downregulated miRNAs in our study (hsa-miR-16, hsa-miR-31, hsa-miR-181b, hsa-miR-184) were found to be upregulated in other miRNA studies in prostate cancer.”
microRNA as Biomarkers and Diagnostics (2016, background): “…studies have shown altered miRNA profiles in multiple cancer types, such as breast cancer (Iorio et al., 2005), leukemia (Calin et al., 2004a), liver cancer (Qi et al., 2013), ovarian cancer (Iorio et al., 2007), pancreatic cancer (Wang and Sen, 2011), and prostate cancer (Porkka et al., 2007).”
WBSMDA: Within and Between Score for MiRNA-Disease Association prediction (2016, result): “For example, the expression of hsa-mir-143 (1st in the prediction list) and hsa-mir-199a (4th in the prediction list) is different in PN compared with the benign prostatic hyperplasia samples 71 .”