Human embryonic stem cells express a unique set of microRNAs.

By M. Suh, Yoontae Lee, Jung Yeon Kim, Soo-Kyoung Kim, S. Moon, Ji Yeon Lee, K. Cha, H. Chung, H. Yoon, S. Moon and 2 more. Developmental Biology, 2004

1,023 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7e0c7ba1965870eab62ace07c1f7f25a162d455f

How researchers see this paper

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In Cancer Research

1. David P. Bartel
2. Scott M. Hammond
3. V. Narry Kim
4. Isaac Bentwich
5. Phillip A. Sharp
6. J. Ruby
7. Young‐Kook Kim
8. Richard A. Young

In Molecular Biology

1. David P. Bartel
2. Scott M. Hammond
3. Richard A. Young
4. V. Narry Kim
5. Phillip A. Sharp
6. Isaac Bentwich
7. R. Jaenisch
8. J. Ruby

Citations in the corpus

• Regulation of miRNA expression during neural cell specification (2005, methodology): “(2003) were the first to catalogue miRNA expression in ES cells using expression cloning, and a similar study has also been performed with human stem cells (Suh et al., 2004).”
• microRNAs as oncogenes and tumor suppressors. (2007, background): “, 2000), stem cell division (Cheng et al., 2005b; Hatfield et al., 2005; Houbaviy et al., 2003; Suh et al., 2004; Zhang et al., 2006f), apoptosis (Cheng et al.”
• TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “Previously, we and other groups reported that mature let-7 appears only after differentiation in embryonic stem (ES) cells, while the levels of pri- and prelet-7 are comparable between undifferentiated and differentiated ES cells, suggesting a posttranscriptional control in let-7 biogenesis (Suh et ”
• The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, neutral): “It is also important to note that the specific processing of individual miRNAs adds a new level of complexity; that is, it is conceivable that there is a cell-typedependent and context-dependent dimension to post-transcriptional silencing.(14,15,33,34)”
• Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “A subset of miRNAs is preferentially expressed in ES cells or embryonic tissue (Houbaviy et al., 2003; Suh et al., 2004; Houbaviy et al., 2005; Mineno et al., 2006).”
• MicroRNAs: key regulators of stem cells (2009, background): “A similar study in human ES cells also shows that pluripotent stem cells have unique miRNAs, the levels of which decrease following differentiatio”
• Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, background): “Sequencing of small RNAs from both mouse and human ES cells has revealed a miRNA population distinct from those of other cells and tissues (Houbaviy et al. 2003; Suh et al. 2004; Calabrese et al. 2007; Morin et al. 2008).”