Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
By J. Cogswell, James Ward, I. Taylor, M. Waters, Yunling Shi, B. Cannon, Kevin Kelnar, Jon Kemppainen, D. Brown, Caifu Chen and 5 more. Journal of Alzheimer's Disease, 2008
923 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/78b635fa27cd4efc06eca7709050fbdca531794a
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Citations in the corpus
- Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood (2014, background): “The nervous system is a rich source of miRNA expression and a number of deregulated miRNA have been found to contribute to other neurodegenerative disorders such as Alzheimer’s disease, including hsa-miR-9, hsa-miR-20a and hsa-miR132 (36).”
- miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “In Alzheimer’s disease, miRNA alterations can be detected both in the brain and cerebrospinal fluid (CSF) of the patients, and also in the biological fluids, such as plasma and serum, making them potential candidates as biomarkers [275].”
- The Role of MicroRNAs in Human Diseases (2010, background): “Dysregulated miRNA expression has been reported in the brain of Alzheimer patients (135) .”
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “MicroRNAs in Biological Fluids Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovar”
- Circular RNA (circRNA) in Alzheimer's disease (AD) (2013, background): “…or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; ∗p < 0.001 (ANOVA). contribute to the down-regulation of selective miRNA-7-sensitive messenger RNA (mRNA) targets (Cogswell et al., 2008; unpublished observations).”