Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression.

By Sidney H. Kennedy, K. Evans, S. Krüger, Helen S. Mayberg, J. Meyer, S. McCann, Andrew I. Arifuzzman, S. Houle, F. Vaccarino. American Journal of Psychiatry, 2001

687 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/508fec51fae8cd80db3af746dabb559ba5dad04b

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Citations in the corpus

Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. (2007, neutral): “In addition to showing increased metabolism in depression (Drevets et al 2002; Kennedy et al 2001), the subgenual cingulate tends to show reduced volume (Botteron et al 2002; Drevets et al 1997; Hirayasu et al 1999; Ongur et al 1998).”
Neurobiology of emotion perception II: Implications for major psychiatric disorders. (2003, background): “…has been associated predominantly with increased metabolism and blood flow within dorsomedial and dorsolateral prefrontal cortices (Baxter et al 1989; Brody et al 1999; Buchsbaum et al 1997; Kennedy et al 2001; Mayberg et al 1999, 2000) and the dorsal anterior cingulate gyrus (Kennedy et al 2001).”
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009, result): “…vmPFC/ rACC, with some studies reporting decreased (e.g., Drevets et al., 1997; Ito et al., 1996; Mayberg et al., 1994) and others increased (e.g., Kennedy et al., 2001; Videbech et al., 2002) activity, and decreased resting rACC activity has been found to predict a poor response to treatment…”
Cellular changes in the postmortem hippocampus in major depression. (2004, methodology): “Other evidence of dissimilarities between prefrontal cortex and hippocampus in depression comes from the work of Mayberg and colleagues (Kennedy et al 2001; Mayberg et al 2000, 2002).”
Adult hippocampal neurogenesis in depression (2007, background): “Structures that show changes in metabolic activity include the subgenual cingulate, hippocampus and prefrontal corte”
Posttraumatic stress disorder: a state-of-the-science review. (2006, methodology): “Kennedy et al. (2001) carried out a similar study of brain glucose metabolism among 13 depressed male patients before and after 6 weeks of therapy with paroxetine 20–40 mg daily, comparing the patterns obtained with those of 24 healthy male volunteers.”
A Research Agenda For DSM-V (2002, background): “Similarly, resting metabolism and its change in response to pharmacologic and psychotherapeutic intervention has been related to treatment response in depression (Brody et al. 1999, 2001; Kennedy et al. 2001; Yildiz et al. 2001a) and OCD (Baxter et al.”
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus (2010, result): “This seed is similar to other subgenual ROIs reported in the literature with depression- related differences (19, 20, 27), although slightly less ventral than some subgenual regions (17, 27).”
The Physiology of Willpower: Linking Blood Glucose to Self-Control (2007, positive): “…individuals exhibit lower levels of cerebral glucose in brain regions responsible for emotion regulation (Drevets, 2000), and increasing the flow of glucose to these regions is associated with recovery from depression (Buchsbaum et al., 1997; S. H. Kennedy et al., 2001; Mayberg et al., 2000).”
Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. (2004, methodology): “The localization and pattern of changes seen in the paroxetine group, including the unique changes in subgenual cingulate (BA 25), insula, and brainstem, replicate previous human and animal metabolic studies of various pharmacotherapies, including other selective serotonin reuptake inhibitors and tr”
Depression: perspectives from affective neuroscience. (2002, background): “Treatment studies have found that activation in dorsolateral PFC, particularly on the left side, increases following successful antidepressant treatment (Kennedy et al. 2001).”
Limbic-frontal circuitry in major depression: a path modeling metanalysis (2004, methodology): “…Drevets et al., 1997; Mayberg et al., 1997; Rajkowska, 2000), treatment effects (latF9, aTh, Cg25, OF11, mF10; (Buchsbaum et al., 1997; Kennedy et al., 2001; Mayberg et al., 2000; Saxena et al., 1999), and response prediction (Cg24; (Kennedy et al., 2001; Mayberg et al., 1997; Wu et al., 1999).”