Cellular changes in the postmortem hippocampus in major depression.

By C. Stockmeier, G. Mahajan, L. Konick, J. Overholser, G. Jurjus, H. Meltzer, Harry B. M. Uylings, L. Friedman, G. Rajkowska. Biological Psychiatry, 2004

714 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/cfd1eb711e73be07389e2307b3203a34544f1f6f

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Citations in the corpus

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, background): “Cellular changes in the postmortem hippocampus and neuronal and glial cell modifications have been also observed (Stockmeier et al. 2004).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Analysis of postmortem hippocampal tissue reveals increases in neuronal and glial density that are observed in conjunction with decreases in the size of neuronal cell bodies, which suggests that reduced neuropil may underlie atrophy of the hippocampus in patients with MDD (Stockmeier et al., 2004).”
The brain and the stress axis: The neural correlates of cortisol regulation in response to stress (2009, background): “differential neuronal and glial packing density, as well as differences in neuronal soma sizes (Stockmeier et al., 2004), how this exactly”
The stress system in the human brain in depression and neurodegeneration. (2005, result): “Since in most older studies, shrinkage-sensitive density measures were used to assess structural changes, thismayhave caused a biaswhen counting cell numbers, and alsomethodological differences may therefore have contributed to the previous results in chronically stressed rats (Swaab and Uylings, 19”
Adult hippocampal neurogenesis in depression (2007, background): “Histological analysis of the dentate gyrus of depressed patients shows a significant increase in packing density of dentate granule cells and a trend toward a reduction in soma siz”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “…to atrophy and retraction of the apical dendrites of hippocampal pyramidal cells; this effect leads to a reduction in the amount of neuropil without frank cell loss, reminiscent of what has been documented in the post-mortem hippocampus of patients with major depression (Stockmeier et al, 2004).”
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. (2011, background): “There is also evidence that neurodegeneration is characteristic of depression (Goshen et al., 2008; Campbell and MacQueen, 2006; Stockmeier et al., 2004; Duman, 2002).”
Brain on stress: How the social environment gets under the skin (2012, background): “Autopsy studies on depression suicide have indicated loss of glial cells and smaller neuron soma size (56), which is indicative of a smaller dendritic tree.”
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats (2010, neutral): “…tissue of depressed patients has revealed minor structural alterations at the level of astrocyte (Muller et al. 2001), cytogenesis (Boldrini et al. 2009; Lucassen et al. 2010b) and neuron (Stockmeier et al. 2004) density, but possible changes in total neuron numbers have not been addressed.”
Neurocircuitry of Mood Disorders (2010, background): “…cortex, and ventral striatum (Baumann et al, 1999; Bowen et al, 1989; O ¨ ngür et al, 1998a, b; Rajkowska et al, 1999), and greater decrements in volume following fixation (implying a deficit in neuropil) in the hippocampus (Stockmeier et al, 2004) in MDD and/or BD subjects relative to controls.”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “Enhancement of 5-HT transmission in MDD also may compensate for the abnormalities in density and sensitivity of some 5-HT receptor subtypes evidenced by post mortem, neuroimaging and pharmacological challenge studies of depression (Stockmeier 2003).”