Adult hippocampal neurogenesis in depression

By Amar Sahay, R. Hen. 2007

1,229 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. R. Hen
4. Guo-li Ming
5. E. Gould
6. Sebastian Jessberger
7. B. Leuner
8. K. Vadodaria

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. R. Hen
5. E. Gould
6. B. Leuner
7. Sebastian Jessberger
8. K. Vadodaria

In Genetics

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. Sebastian Jessberger
5. K. Vadodaria
6. R. Hen
7. E. Pasquale
8. E. Gould

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Adult hippocampal neurogenesis has also been suggested to be required for certain, but not all, antidepressant-induced behavioral responses in specific strains of mice (reviewed by Sahay and Hen, 2007; Sahay et al., 2011 in this issue).”
• Modification of hippocampal circuitry by adult neurogenesis (2012, background): “…clearance of hippocampal memory traces, reorganization of memory to extrahippocampal substrates, and certain antidepressant-induced behavioral responses in Developmental Neurobiology specific mouse strains (Sahay and Hen, 2007; Deng et al., 2010; Aimone et al., 2011; Sahay et al., 2011).”
• Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, neutral): “…ª2011 Elsevier Inc. for firing of young adult-born neurons, their insensitivity to GABAergic inhibition, and their connections with interneurons and mossy cells in the DG hilar microcircuit (Figure 2; Sahay and Hen, 2007; Lacefield et al., 2010; see also Doetsch and Hen, 2005; Ming and Song, 2011).”
• Major depressive disorder. (2008, neutral): “sant efficacy may rely on an increase in neurogenesis [54-56].”
• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, neutral): “Exploring the physiologic role of endogenous neurogenesis, particularly that which occurs in the hippocampal dentate gyrus, has important relevance to the study of psychiatric disease (56).”
• The molecular neurobiology of depression (2008, neutral): “A marked cellular effect of several, but not all, antidepressant treatments is the induction of adult hippocampal neurogenesis — the process by which neural progenitors of the hippocampal subgranular zone (SGZ) divide mitotically to form new neurons that differentiate and integrate into the dentate ”
• Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months (2011, background): “For example, there has been much interest in links between neurogenesis and the effectiveness of antidepressant therapies (47, 48).”
• Depression as a microglial disease. (2015, background): “The key involvement of impairments in these processes in the pathogenesis of depression [112,113,184] suggests that a decline in microglial functioning may induce depression via its detrimental effects on these processes.”
• Antidepressants increase neural progenitor cells in the human hippocampus (2009, background): “Adult neurogenesis appears to be functional since abolishing it affects hippocampal-dependent learning (Van Praag et al, 2002; Sahay and Hen 2007).”
• Eph-ephrin bidirectional signaling in physiology and disease. (2008, background): “In particular, the integration of newly generated neurons in the hippocampal circuitry seems to be important for the behavioral effects of antidepressants, an area where the involvement of Eph receptors has not yet been explored (Sahay and Hen, 2007).”
• Structural Plasticity and Hippocampal Function (2010, background): “However, the potential role for adult hippocampal neurogenesis as a mechanism underlying the etiology and treatment of mood disorders remains a matter of intense discussion and investigation (reviewed in Sahay & Hen 2007, Sapolsky 2004).”
• Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “…centrally the nucleus accumbens, VTA, hypothalamus, bed nucleus of stria terminalis—all systems centrally involved in separation distress) and may play a central role in mood regulation, including regulation of both the mesolimbic dopamine system and the HPA stress axis (Sahay & Hen, 2007).”
• Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “, 2003), and cognitive defects characteristic of depression (Sahay and Hen, 2007; Mateus-Pinheiro et al., 2013) and schizophrenia (SCZD) (Reif et al.”
• Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “For example, stress decreases granule cell precursor proliferation in mice, rats, and marmosets, while antidepressant treatments increase cell proliferation in all tested species (Malberg et al., 2000; Mirescu and Gould, 2006; Sahay and Hen, 2007).”