Cells release prions in association with exosomes.

By Benoît Février, D. Vilette, F. Archer, D. Loew, W. Faigle, M. Vidal, H. Laude, G. Raposo. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,024 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4a19a5604e8b277420708420755a7c80d725af8f

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Citations in the corpus

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “Exosomes are secreted by neural, epithelial, muscle and stem cells, and their range of proposed functions include contribution to tissue repair (exosomes secreted by mesenchymal stem cells modify host cardiac tissue) (89), communication within the nervous system (exosomes are secreted by neurons, Sc”
Membrane microparticles: two sides of the coin. (2005, background): “(16), as previously described for the normal cellular form, PrPc, in MPs (21).”
Exosomes: secreted vesicles and intercellular communications (2011, background): “involved in the formation/transfer of pathogenic proteins (such as prions and amyloid deposits) [31,32].”
Exosomal-like vesicles are present in human blood plasma. (2005, background): “More recently, several studies have shown that non-hematopoietic cells such as intestinal epithelial cells (18), neuroglial cells ( 19 ) and tumor cells (20–23) also have the ability to release exosomes.”
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication (2013, background): “Several pathogenic proteins involved in CNS diseases, such as prions [18], b-amyloid peptide [77], superoxide-dismutase [78], and asynuclein [79] are released from cells in association with exosomes.”
Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival (2010, background): “…that exosome-mediated export could play a critical role in the processing of proteins associated with neurodegenerative diseases, because -amyloid (A ) peptides and prions were found to be externalized from cells via this pathway (Fevrier et al., 2004; Rajendran et al., 2006; Vella et al., 2008).”
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “Many different cell types such as B cells [23], dendritic cells [25], mast cells [25], T cells [49], platelets [50], Schwann cells [34], tumor cells [51], mesenchymal stem cells [32], human embryonic kidney cell [52], various”
Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. (2007, neutral): “It has been also postulated that MVs may contribute in spreading certain infective agents such as HIV or prions.(16,17) Embryonic stem cells have recently shown to represent an abundant source of MVs and it has been suggested that MVs derived from these cells may represent one of the critical compon”
Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles (2013, background): “This fully corroborates the observations that cells contain different MVBs and that within MVBs, ILVs are not all similar in morphology and composition (Fevrier et al., 2004; Möbius et al., 2002; White et al., 2006).”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “are infectious, they are likely to contribute to the spreading of prions (Fevrier et al., 2004; Vella et al., 2007).”