Membrane microparticles: two sides of the coin.

By B. Hugel, M. C. Martı́nez, C. Kunzelmann, J. Freyssinet. Physiology, 2005

722 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Obstetrics and Gynecology

View Paper: https://www.semanticscholar.org/paper/2133967c672717118ba359bb772bec8874605a2c

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Citations in the corpus

Physiological role of indigenous milk enzymes: An overview of an evolving picture (2006, background): “Microvesicles, with a diameter in the range 100–1000 nm, originate from the cell surface membrane and are shed directly into the extracellular space, a process that seems to be important for membrane turnover, tumor ganglioside metabolism and vascular regulation (Hugel et al., 2005).”
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. (2009, background): “Studies have shown that phosphatidylserine (PS) externalization accompanies shedding of plasma membrane-derived microvesicles [11].”
Membrane vesicles as conveyors of immune responses (2009, background): “The secretion of microvesicles or ectosomes by blood cells is regulated by various stimuli that lead to increased intracellular calcium levels, which induces plasma membrane remodelling and vesicle sheddin”
Microvesicles: mediators of extracellular communication during cancer progression (2010, background): “Phosphatidylserine is relocated to the outer membrane leaflet, specifically at sites on the cell surface where microvesicle shedding occurs, while the topology of membrane proteins remains intact (Hugel et al., 2005; Lima et al., 2009; Muralidharan-Chari et al., 2009a) (see Fig.”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “The absence in secreted EVs of flippase, the enzyme that actively generates asymmetrical distribution of phospholipids in the PM of live cells, is probably responsible for PS exposure on secreted vesicles (Hugel et al. 2005).”
Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “These mechanisms include alterations in activity of enzymes that transfer lipids from one leaflet of the plasma membrane, such as flippases, floppases, and scramblases [41].”
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model (2013, background): ““Exosomes” refer to those vesicles of 50–100 nm in diameter and “MVs” for the larger extracellular membrane vesicles (100–1,000 nm in diameter) [29].”
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “The biogenesis and release of MVs from the plasma membrane is dependent on a number of processes, reviewed elsewhere (65).”
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, positive): “Membrane budding/vesicle formation is induced by translocation of phosphatidylserine to the outer-membrane leaflet [62, 65].”
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. (2014, background): “The amount of MVs released by the cells seems to correlate with their “state of activation” and perhaps in response to local change of tissue microenvironment [12].”
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs (2009, background): “Increasingly, intercellular exchange of microparticles is seen as an important mode of intercellular communication (1).”