Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.

By M. Deregibus, Vincenzo Cantaluppi, Raffaele Calogero, Marco Lo Iacono, Ciro Tetta, Luigi Biancone, Stefania Bruno, B. Bussolati, Giovanni Camussi. Blood, 2007

982 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a01681dcaa7af87aa6766db631893b85b34bfdd6

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Citations in the corpus

The biology and function of exosomes in cancer. (2016, positive): “Different types of RNAs, including mRNA and noncoding RNAs such as miRs and lncRNAs (8, 14, 32), in exosomes are functional and can impact the transcriptome of recipient cells (8, 14, 33, 34).”
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, neutral): “In 2007, Camussi’s group (84) isolated microvesicles from endothelial progenitor cells (EPCs) which they later deduced had contained proangiogenic miR-126 and miR-296 (85).”
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. (2010, positive): “…cell types (Rosell et al., 2009; Taylor and Gercel-Taylor, 2008), peripheral blood cells (Hunter et al., 2008; Valadi et al., 2007), endothelial progenitor cells (Deregibus et al., 2007), and embryonic stem cells (Ratajczak et al., 2006) have been shown to secrete RNA-containing microvesicles.”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, neutral): “Microvesicles and exosomes are both commonly found in extracellular fluids and may be produced by the same cell type (51, 52).”
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model (2013, positive): “It has been proven that EVs can be released by various stem cells and progenitors [11, 12] including MSCs [13, 14].”
Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection (2009, positive): “Whereas apoptotic bodies induce proliferation and differentiation of endothelial progenitor cells in vitro, which implies a role in tissue repair and angiogenesis (7, 9), they can also be engulfed by phagocytes, which triggers the secretion of cytokines or growth factors, such as vascular”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, neutral): “However, some groups instead use RNAse digestion to show that the functional activity of their EVs requires RNA (Deregibus et al. 2007).”
Biological properties of extracellular vesicles and their physiological functions (2015, positive): “EVs derived from mononuclear blood cells are reportedly involved in horizontal mRNA transfer and induce pro-angiogenic effects in vitro and in vivo (186).”