Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

By C. Frühbeis, Dominik Fröhlich, W. Kuo, Jesa Amphornrat, S. Thilemann, Aiman S. Saab, F. Kirchhoff, W. Möbius, S. Goebbels, K. Nave and 5 more. PLoS Biology, 2013

800 citations recorded by the source corpus.

Neuronal activity provokes myelinating oligodendrocytes to release exosomes by stimulation of ionotropic glutamate receptors, and that once released, these vesicles are internalized by neurons conveying neuroprotection.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/60ce88e5683363e2099d07fcdb06b6dc8bcbaceb

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In Cancer Research

1. Marina Colombo
2. C. Théry
3. X. Breakefield
4. G. Raposo
5. M. Wood
6. P. Vader
7. Yan Luo
8. Ben Wang

In Molecular Biology

1. C. Théry
2. X. Breakefield
3. Marina Colombo
4. G. Raposo
5. P. Vader
6. M. Wood
7. María Yáñez-Mó
8. Zoraida Andreu

Citations in the corpus

• Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “However, depending on the recipient cell type, clathrin–dynamin–caveolae-dependent endocytosis and pinocytosis mechanisms may also operate (116, 117).”
• Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “Frühbeis et  al. have shown that silencing of Rab35 results in inhibition of release of proteolipid protein- and ALIX-expressing EXOs (63) from primary oligodendrocytes.”
• Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “In the central nervous system, exosomes secreted by oligodendrocytes have been associated with enhanced neuronal viability and an increase in neuron firing rate [111,112].”
• Exosome Theranostics: Biology and Translational Medicine (2018, background): “Exosomes contribute to fundamental physiological processes, such as neuronal communication [4], antigen presentation [5], immune responses [6], organ development [7], and reproductive performances [8].”
• Biogenesis and secretion of exosomes. (2014, neutral): “Inhibition of RAB35 impaired PLP-bearing exosome secretion in oli-neu cells [62], and in primary oligodendrocytes [64].”
• SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “For instance, calcium entry through NMDA and AMPA receptors triggers oligodendroglial exosome secretion, which improves viability of the recipient neuronal cells upon exposure to conditions of cell stress [107].”
• Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “…shown that the release of EVs is also an important mediator of intercellular communication that is involved in normal physiological process as well as in pathological progression (Frühbeis et al. 2012, 2013; Marcilla et al. 2012; Luga et al. 2012; Regev-Rudzki et al. 2013; Barteneva et al. 2013).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “…for instance, that HSC70 (HSPA8) and HSP70 (HSPA1A/B), flotillin-1, and milk fat globule-EGF-factor VIII (MFGE8, also called lactadherin) equilibrate at slightly different densities than does ALIX (PDCD6IP) or CD9 (Baietti et al. 2012, Bobrie et al. 2012a, Fruhbeis et al. 2013, Tauro et al. 2012).”