Exosomes: secreted vesicles and intercellular communications

By C. Théry. F1000 Biology Reports, 2011

950 citations recorded by the source corpus.

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and are thought to play important roles in intercellular communications. Although exosomes were originally described in 1983, interest in these vesicles has really increased dramatically in the last 3 years, after the finding that they contain mRNA and microRNA. This discovery sparked renewed interest for the general field of membrane vesicles involved in intercellular communications, and research on these structures has grown exponentially over the last few years, probing their composition and function, as well as their potential value as biomarkers.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b0de97aeca5461b3cac0f63947f542eafc73d7e9

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Citations in the corpus

Innovative approaches for cancer treatment: current perspectives and new challenges (2019, background): “Specifically, exosomes are small vesicles of around 30–150 nm originated from endosomes in physiological and pathological conditions and released by a fusion of multivesicular bodies (MVBs) to the cell membrane [55, 56], while shed microvesicles (sMVs), with a typical size of 50–1,300 nm, are presen”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “Recent studies have shown that they are specialized in long-distance intercellular communications [40,41] facilitating transfer of proteins [42,43], and functional mRNAs and microRNAs for subsequent protein expression in target cells [44,45].”
Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis (2013, background): “The existence of secretory RNAhas been known formany years (4, 5), and recent reports have shown that miRNAs (6), which regulate various types of biological phenomena through the regulation of a variety of target genes, are secreted from cells via the exosome (7, 8).”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “Several recent studies demonstrated that exosomes are secreted by multiple cell types, including cancer cells, stem cells, immune cells, and neurons (Théry, 2011).”