Classification, Functions, and Clinical Relevance of Extracellular Vesicles

By Edwin van der Pol, A. Böing, P. Harrison, A. Sturk, Rienk Nieuwland. Pharmacological Reviews, 2012

1,652 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/04d3a22a23d882a2e03c36ce1e513d24633a51b7

How researchers see this paper

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In Biomedical Engineering

1. D. Lyden

In Molecular Biology

1. Marina Colombo
2. T. Whiteside
3. C. Théry
4. E. Batrakova
5. M. Kim
6. Dihua Yu
7. Lin Zhang
8. Jan Lötvall

Citations in the corpus

• Exosomes in cancer development, metastasis, and immunity (2019, background): “The ApoEVs range in diameter from 1000 nm to 5000 nm, and they contain the nuclear protein histone and DNAs [8].”
• Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes (2013, background): “In general, centrifugal force at 200 1,500 g are used to pellet cells and ‘‘cellular debris,’’ 10,000 20,000 g to pellet vesicles with a size between 100 and 800 nm (generally called MVs) and between 100,000 and 200,000 g to pellet the smallest vesicles with a diameter B100 nm (generally referred to”
• Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “Exosomes comprise one of the main subclasses of EVs and have an endosomal origin [15].”
• Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes (2016, background): “The surface receptors of EVs allow their targeting and capture by recipient cells, which can then incorporate proteic, lipidic, and even genetic messages carried by the vesicles, resulting in modifications of their physiological state (1, 4, 5).”
• Tumor-derived exosomes and their role in cancer progression (2016, background): “In addition to size, EVs also differ from one another by cellular mechanisms used for their secretion, molecular content and functional properties [3, 4].”
• A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option? (2020, background): “The presence of exosomes was relatively ignored (classified as ‘cellular dust’) until interest was revived with discoveries demonstrating their capacity to serve as mediators of intercellular communication [9], potential drug delivery vectors [10], and bio-markers of various chronic and acute diseas”
• Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “In this review we summarize the metastatic role of various EVs: microvesicles, exosomes, ectosomes, oncosomes, cytoplast etc (Colombo et al., 2014; Di Vizio et al., 2012; Headley et al., 2016; Thery et al., 2009; van der Pol et al., 2012).”
• Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “Recent studies have shown that they are specialized in long-distance intercellular communications [40,41] facilitating transfer of proteins [42,43], and functional mRNAs and microRNAs for subsequent protein expression in target cells [44,45].”
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “EV are a heterogeneous group, and the nomenclature is still being defined and refined by the research community (19 (cid:2) 21).”