Exosomal-like vesicles are present in human blood plasma.

By Marie-Pierre Caby, D. Lankar, C. Vincendeau-Scherrer, G. Raposo, C. Bonnerot. International Immunology, 2005

1,338 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3509092a738ef3b3f4e3953eacb52f7fa6389f11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Théry
2. G. Raposo
3. Richard J. Simpson
4. J. Schorey
5. Suresh Mathivanan
6. W. Stoorvogel
7. Guillaume van Niel
8. V. Pascual

In Molecular Biology

1. C. Théry
2. G. Raposo
3. Suresh Mathivanan
4. Richard J. Simpson
5. A. Llorente
6. Asfar S. Azmi
7. Fazlul H. Sarkar
8. Bin Bao

Citations in the corpus

• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “plasma (34,35), ocular effluent and aqueous humor (36),”
• Circulating microRNAs as stable blood-based markers for cancer detection (2008, background): “Exosomes are 50- to 90-nm (24), membrane-bound particles that have been reported to be abundant in plasma (25) and that have recently been shown (in cell culture studies) to contain miRNAs (26).”
• CANCER-ASSOCIATED FIBROBLAST EXOSOMES REGULATE SURVIVAL AND PROLIFERATION OF PANCREATIC CANCER CELLS (2016, positive): “To investigate this further, CAFs were transduced with a lentiviral vector that allowed the visualization of exosomes by labeling CD63, a known exosome marker (20), with Green Fluorescent Protein (GFP).”
• Engineering exosomes for targeted drug delivery (2021, background): “Exosomes are now widely found in all bodily fluids and tissues, including blood [6], urine [7], breast milk [8], amniotic/synovial/ascites fluid [9], saliva [10], and adipose tissue [11].”
• High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients (2009, background): “Exosomes are microvesicles produced by virtually all cells, but their secretion is known to be constitutively exacerbated in tumor cells, and several groups including ours, have reported the presence of exosomes of likely tumor origin in plasma and other biological fluids from cancer patients [10,16”
• Membrane vesicles as conveyors of immune responses (2009, background): “In addition, membrane vesicles and/or exosomes have been purified in the absence of any mechanical dissociation from several body fluids, such as human plasm”
• Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “…exosomes have been isolated from diverse body fluids, including semen (Ronquist and Brody, 1985; Park et al., 2011; Aalberts et al., 2012), blood (Caby et al., 2005), urine (Pisitkun et al., 2004), saliva (Ogawa et al., 2011), breast milk (Admyre et al., 2007), amniotic fluid (Asea et al.,…”
• Cellular Internalization of Exosomes Occurs Through Phagocytosis (2010, background): “The presence of exosomes in urine (10,11), circulating blood (12), ascites (13) and cerebrospinal fluid (14) in vivo suggests a role in intercellular communication (15,16).”
• ExoCarta 2012: database of exosomal proteins, RNA and lipids (2011, background): “Recent studies have shown that exosomes can be isolated in vivo in bodily fluids such as blood (8), urine (9), breast milk (10), amniotic fluid (11), malignant ascites (12), bronchoalveolar lavage fluid (13) and synovial fluid (14).”
• EVpedia: a community web portal for extracellular vesicles research (2015, background): “…also found in various biological fluids, such as amniotic fluid, ascites, breast milk, plasma, saliva, semen, serum and urine (Asea et al., 2008; Caby et al., 2005; Cheng et al., 2014a, b; Dai et al., 2008; George et al., 1982; Lässer et al., 2011; Poliakov et al., 2009; Raj et al.,…”
• Biological properties of extracellular vesicles and their physiological functions (2015, result): “Although plasma-derived EVs are a mixture of vesicles from the cells lining the blood vessels and the different cells found in blood, the largest individual population of EVs in plasma is positive for platelet specific markers (such as, CD41a, CD61 andGPIb) and are considered now to be 25% of the to”
• Exosomes with Immune Modulatory Features Are Present in Human Breast Milk1 (2007, background): “They have been shown to be present in physiological fluids such as bronchoalveolar lavage (11), human plasma (12), malignant effusions (13), and urine (14) and on the surface of follicular dendritic cells (15).”