Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery.

By R. Yeo, R. C. Lai, Bin Zhang, S. S. Tan, Yijun Yin, Bao Ju Teh, S. Lim. Advanced Drug Delivery Reviews, 2013

779 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4eeaabf60ab53ae552295dfd34f20875ae6c7463

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Citations in the corpus

MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, positive): “Because they may provide a continuous source of released exosomes, MSCs are an ideal cell source of exosomes for active biofactor delivery [77-79].”
Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. (2015, background): “do and SMVs exhibit a naturally derived composition which results in a reduced immunogenicity [9,10] and they can potentially bypass complement activation and coagulation factors giving them better stability in the blood circulation [11,12].”
The biology, function, and biomedical applications of exosomes (2020, positive): “MSC-derived exosomes have been proposed to be therapeuticbythemselves ( 222 ),andtheuseof MSC-derived exosomes in the treatment of a patient with graft versus host disease showed that repeated injections were well tolerated, were not associated with substantial side effects, and resulted in patient…”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “For example, immature dendritic cells produce limited numbers of EVs [51,59], whereas mesenchymal stem cells produce a large number [60,61].”
Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma (2015, background): “Increasing studies indicate that MSCs are well suited for the mass production of exosomes [17], which may perform important functions in the therapeutic effect of MSCs through paracrine mechanism.”