General translational repression by activators of mRNA decapping.

By J. Coller, R. Parker. Cell, 2005

664 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/41bb005381e27feda95d5533c20251ba51e6d850

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Citations in the corpus

THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION (2010, background): “cerevisiae , which has homologues of RCK, PAT1 and RAP55 (known as Dhh1, Pat1 and Scd6, respectively), the Dhh1 helicase and Pat1 seem to act as partially overlapping regulators of global mRNA translatio”
The Functions of MicroRNAs: mRNA Decay and Translational Repression. (2015, background): “DDX6 is known as a decapping activator but can also function in translational repression at the initiation step and/or at the elongation step [100,101].”
Eukaryotic stress granules: the ins and outs of translation. (2009, background): “…mRNAs are often localized prior to translation (Martin and Ephrussi, 2009), translation initiation and mRNA degradation are often inversely related (Coller and Parker, 2004), and mRNA decay and translation repression mechanisms share similar proteins (Holmes et al., 2004; Coller and Parker, 2005).”
The role of disordered protein regions in the assembly of decapping complexes and RNP granules (2013, background): “Decapping and translation machineries compete for mRNA access, and decapping activators (i.e., DDX6, Pat, and LSm14A) repress translation (Coller and Parker 2005; Marnef et al. 2010; Nissan et al. 2010; Rajyaguru et al. 2012; Sweet et al. 2012); however, their molecular mechanisms have not been…”
Mechanisms of microRNA‐mediated gene regulation (2007, background): “The D. melanogaster homolog of RCK, ME31B, is required for suppression of oskar mRNA translation [61], and the budding yeast homolog of RCK, Dhh1p, is involved in general translational repression [ 62 ].”
A role for the P-body component GW182 in microRNA function (2005, background): “Recent studies indicate that P-bodies represent a pool of translationally repressed messenger ribonucleoproteins (mRNPs), which is in equilbrium with the translating poo”
How do microRNAs regulate gene expression? (2008, background): “In strains deleted for both, the normal response to glucose starvation, which includes the breakdown of polysomes, cessation of translation, and mobilization of all mRNAs into P-bodies, no longer occurred ( 69 ).”
P bodies and the control of mRNA translation and degradation. (2007, background): “Conversely, overexpression of Dhh1p or Pat1p in yeast leads to an inhibition of translation and an increase in P bodies (Coller and Parker, 2005).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “if transcripts get degraded or return to the cytoplasm for active translation [171, 219, 220].”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “For example, the Pat1, Dhh1, and Scd6 proteins all appear to block translation before the formation of a 48S preinitiation complex (Coller and Parker 2005; Nissan et al. 2010).”
P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing (2007, background): “What could be the role of these proteins in P-body formation? Me31B is an RNA helicase which could facilitate rearrangements in mRNP composition upon release from polysomes (14).”
Codon optimality is a major determinant of mRNA stability (2015, methodology): “Ribosomal run-off experiments were performed similarly to normal polyribosome analysis, except cells were resuspended in media lacking glucose for 10 min before harvesting (Coller and Parker, 2005).”
The highways and byways of mRNA decay (2007, background): “Dhh1 and Pat1 have a role in mediating translational repression as well as decappin”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “P-body-resident proteins such as RCK/p54 (and the yeast orthologue Dhh1”