THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION

By R. Jackson, C. Hellen, T. Pestova. Nature reviews. Molecular cell biology, 2010

2,824 citations recorded by the source corpus.

Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation complexes, have advanced our understanding of the complex translation initiation process. These developments have provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity (which affects almost all scanning-dependent initiation) and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c44aeb32bd258354e6d1da5b9a15cd53bd1ce23

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Citations in the corpus

Non-ATG–initiated translation directed by microsatellite expansions (2010, methodology): “Some IRESs, such as the one in the cricket paralysis virus, can facilitate translation initiation without eIFs or tRNAi Met (1).”
Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. (2017, background): “It is known that meIF3 interacts with eIF4G, bridging interaction between eIF3 in the 43S PIC and the eIF4F-mRNP [2].”
The integrated stress response (2016, positive): “Exchange of GDP for GTP is catalyzed by a guanine nucleotide exchange factor eIF2B, and this converts eIF2 back to its active form [87,88].”
The initiation of mammalian protein synthesis and the mechanism of scanning (2013, background): “This pocket is formed by the 18S rRNA helices h28, h44 of the body, h24 of the platform, h28, h29, h30, h31 of the head domains and by three ribosomal proteins (rpS) located in the head of 40S subunit: rpS15(19), rpS16(9) and rpS18(13) (Fig.”
mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “mRNA translation and decay Eukaryotic mRNA translation initiation is an exquisitely regulated process involving the assembly of a multiprotein–RNA complex that directs ribosomes to the initiation codon.(20) Generally, Cap-dependent translation begins with the cap Fig.”
A census of human RNA-binding proteins (2014, background): “Regulatory RBPs control correct translation, monitor stability, decay and localization, and shuttle mRNAs between active translation, stress granules and P bodies (Buchan and Parker, 2009; Dreyfuss et al., 2002; Glisovic et al., 2008; Jackson et al., 2010; Müller-McNicoll and Neugebauer, 2013; Parke”
How RNA binding proteins interact with RNA: molecules and mechanisms (2020, background): “ATP hydrolysis subsequently promotes conformational changes that cause the helicase to translocate 1 nt and/or unwind its substrate (Iost et al., 1999; Jankowsky, 2011; Jiang et al., 2011; Kainov et al., 2003).”
Pharmacological brake-release of mRNA translation enhances cognitive memory (2013, background): “Paradoxically, under conditions of reduced protein synthesis, a small group of mRNAs that contain upstream open reading frames (uORFs) in their 5′UTR are translationally up-regulated (Hinnebusch, 2005; Jackson et al., 2010).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, methodology): “Initiation of translation [1763, 1660, 1764, 1765, 1766, 1767, 1782, 1770, 1771, 1772] is a multi-step kinetic process and involves several initiation-factors [1773, 1774, 1775, 1781].”